Frmd7 - FERM domain containing 7 Gene

Also Known as Gm1533; EG665849

Species: Mus musculus

Gene Type: protein coding
Gene ID: 385354

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in regulation of neuron projection development. Acts upstream of or within several processes, including negative regulation of stress fiber assembly; positive regulation of lamellipodium assembly; and positive regulation of small GTPase mediated signal transduction. Located in growth cone and neuronal cell body. Is expressed in brain; eye; heart; and lung. Used to study congenital nystagmus 1. Human ortholog(s) of this gene implicated in congenital nystagmus 1. Orthologous to human FRMD7 (FERM domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Frmd7 Products (1)

mRNA Protein Name
NM_001190332.2 NP_001177261.1 FERM domain-containing protein 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23967341 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of protein binding IDA
IDA: Inferred from direct assay
23967341 MGI
acts upstream of or within negative regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
23967341 MGI
acts upstream of or within positive regulation of lamellipodium assembly IDA
IDA: Inferred from direct assay
23967341 MGI
acts upstream of or within positive regulation of small GTPase mediated signal transduction IGI
IGI: Inferred from genetic interaction
23967341 MGI
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
19892780 MGI
Cellular Component GO Annotation Evidence References Source
located in growth cone IDA
IDA: Inferred from direct assay
19892780 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
19892780 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
19892780 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FERM domain-containing protein 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05105 FRMD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Frmd7 NCBI NCBI:90167