2. Gene
  3. Mir21a - microRNA 21a Gene

Mir21a - microRNA 21a Gene

  • Gene
  • Agent
Mus musculus

Also known as Mir21; Mirn21; mmu-mir-21; mmu-mir-21a

Gene ID: 387140 | Gene type: ncRNA

About Mir21a

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mRNA 3'-UTR binding IEP
IEP: Inferred from expression pattern
25504627 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to decreased oxygen levels IEP
IEP: Inferred from expression pattern
19147652 MGI
acts upstream of or within cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
24391219 MGI
acts upstream of or within cellular response to granulocyte macrophage colony-stimulating factor stimulus IEP
IEP: Inferred from expression pattern
24391219 MGI
acts upstream of or within cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
24391219 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
24391219 MGI
acts upstream of or within female pregnancy IDA
IDA: Inferred from direct assay
18556655 MGI
acts upstream of or within inflammatory response to antigenic stimulus IDA
IDA: Inferred from direct assay
22517757 MGI
involved in miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
29925839 MGI
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IEP
IEP: Inferred from expression pattern
19147652 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19147652 MGI
acts upstream of or within positive regulation of cell growth IDA
IDA: Inferred from direct assay
24391219 MGI
acts upstream of or within positive regulation of cell growth IGI
IGI: Inferred from genetic interaction
24391219 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
22517757 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
18556655 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within response to muscle activity IDA
IDA: Inferred from direct assay
20086200 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
18723672 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RISC complex IDA
IDA: Inferred from direct assay
22503104 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RI02842A mmu-miR-21a-3p antagomir 93.25% Unkown
HY-RS22356 Vmp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-R02842 mmu-miR-21a-3p mimic / Unkown
HY-R02842A mmu-miR-21a-3p agomir / Unkown
HY-RI02842 mmu-miR-21a-3p inhibitor / Unkown
HY-R04615 mmu-miR-21a-5p mimic 99.41% Unkown