2. Gene
  3. Mir134 - microRNA 134 Gene

Mir134 - microRNA 134 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn134; mir-134; mmu-mir-134

Gene ID: 387152 | Gene type: ncRNA

About Mir134

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular metabolic process IMP
IMP: Inferred from mutant phenotype
25124681 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
25124681 MGI
acts upstream of or within long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
25858512 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
18806776 MGI
acts upstream of or within ossification IDA
IDA: Inferred from direct assay
25751060 MGI
Cellular Component GO Annotation Evidence Reference Source
located in postsynaptic density IDA
IDA: Inferred from direct assay
22897173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00256 hsa-miR-134-5p mimic 94.77% Unkown
HY-R04607 hsa-miR-134-3p mimic 93.71% Unkown
HY-R00256A hsa-miR-134-5p agomir / Unkown
HY-R02668 mmu-miR-134-3p mimic / Unkown
HY-R02668A mmu-miR-134-3p agomir / Unkown
HY-R04229 rno-miR-134-3p mimic / Unkown
HY-R04229A rno-miR-134-3p agomir / Unkown
HY-R04607A hsa-miR-134-3p agomir / Unkown
HY-RI00256 hsa-miR-134-5p inhibitor / Unkown
HY-RI00256A hsa-miR-134-5p antagomir / Unkown
HY-RI02668 mmu-miR-134-3p inhibitor / Unkown
HY-RI02668A mmu-miR-134-3p antagomir / Unkown
HY-RI04229 rno-miR-134-3p inhibitor / Unkown
HY-RI04229A rno-miR-134-3p antagomir / Unkown
HY-RI04607 hsa-miR-134-3p inhibitor / Unkown
HY-RI04607A hsa-miR-134-3p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir134 NCBI NCBI:406924