2. Gene
  3. Mir214 - microRNA 214 Gene

Mir214 - microRNA 214 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn214; mir-214; mmu-mir-214

Gene ID: 387210 | Gene type: ncRNA

About Mir214

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
29363576 MGI
enables sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
29363576 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within cellular response to forskolin IEP
IEP: Inferred from expression pattern
21993888 MGI
acts upstream of or within cellular response to hypoxia IGI
IGI: Inferred from genetic interaction
24011070 MGI
acts upstream of or within cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
25959411 MGI
acts upstream of fatty acid oxidation IDA
IDA: Inferred from direct assay
24011070 MGI
acts upstream of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
24011070 MGI
acts upstream of or within miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
20534588 MGI
acts upstream of or within negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
20534588 MGI
acts upstream of or within negative regulation of fatty acid oxidation IDA
IDA: Inferred from direct assay
24011070 MGI
acts upstream of or within negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
24011070 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20534588 MGI
acts upstream of or within positive regulation of skeletal muscle tissue development IGI
IGI: Inferred from genetic interaction
20534588 MGI
acts upstream of or within positive regulation of skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
20534588 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
18723672 MGI
acts upstream of or within type B pancreatic cell development IDA
IDA: Inferred from direct assay
17804764 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00445 hsa-miR-214-3p mimic 98.31% Unkown
HY-R00445A hsa-miR-214-3p agomir 97.73% Unkown
HY-RI00445A hsa-miR-214-3p antagomir 99.11% Unkown
HY-RI00446 hsa-miR-214-5p inhibitor 99.12% Unkown
HY-R00446 hsa-miR-214-5p mimic / Unkown
HY-R00446A hsa-miR-214-5p agomir / Unkown
HY-R04303 rno-miR-214-3p mimic / Unkown
HY-R04303A rno-miR-214-3p agomir / Unkown
HY-R04304 rno-miR-214-5p mimic / Unkown
HY-R04304A rno-miR-214-5p agomir / Unkown
HY-RI00445 hsa-miR-214-3p inhibitor / Unkown
HY-RI00446A hsa-miR-214-5p antagomir / Unkown
HY-RI04303 rno-miR-214-3p inhibitor / Unkown
HY-RI04303A rno-miR-214-3p antagomir / Unkown
HY-RI04304 rno-miR-214-5p inhibitor / Unkown
HY-RI04304A rno-miR-214-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir214 NCBI NCBI:406996