MIR214 - microRNA 214 Gene
Also Known as MIRN214; mir-214; miRNA214
Species: Homo sapiens
About MIR214
This gene has 1 transcript (splice variant), 154 orthologues and 1 paralogue.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
30703347 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
22336710 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
24158985 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
24158985 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cervical Cancer |
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| Ovarian Cancer |
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| Ovarian Serous Carcinoma |
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| Inclusion Body Myositis |
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| Vascular Disease |
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| Intrahepatic Cholangiocarcinoma |
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| Dermatomyositis |
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| Facioscapulohumeral Muscular Dystrophy 1 |
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| Adrenal Cortical Carcinoma |
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| Nemaline Myopathy |
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| Muscular Dystrophy, Duchenne Type |
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| Miyoshi Muscular Dystrophy 1 |
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| Polymyositis |
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| Kidney Cancer |
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| Heart Disease |
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| Bone Resorption Disease |
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| Bone Remodeling Disease |
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| Squamous Cell Carcinoma, Head And Neck |
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| Pancreatic Cancer |
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| Prostate Cancer |
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| Lung Cancer |
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| Gastric Cancer |
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| Hepatocellular Carcinoma |
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| Bone Sarcoma |
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| Female Reproductive System Disease |
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| Cervix Disease |
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| Bile Duct Adenocarcinoma |
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| Reproductive System Disease |
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| Endocrine Gland Cancer |
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| Bile Duct Cancer |
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| Endocrine System Disease |
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| Bile Duct Disease |
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| Uterine Anomalies |
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| Ovary Epithelial Cancer |
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| Gastrointestinal System Cancer |
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| Stomach Disease |
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| Urinary System Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Biliary Tract Disease |
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| Male Reproductive Organ Cancer |
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| Pleuropulmonary Blastoma |
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| Connective Tissue Cancer |
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| Bladder Disease |
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| Ovarian Disease |
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| Gastrointestinal System Disease |
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| Male Reproductive System Disease |
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| Inverted Papilloma |
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| Large Intestine Cancer |
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| Gallbladder Disease |
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| Intestinal Disease |
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| Thoracic Cancer |
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| Biliary Tract Cancer |
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| Central Nervous System Cancer |
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| Pancreas Disease |
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| Hepatic Vascular Disease |
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| Colonic Disease |
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| Spinal Disease |
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| Glucocorticoid-Induced Osteoporosis |
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| Osteoporosis |
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| Respiratory System Cancer |
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| Lymphatic System Cancer |
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| Cervix Carcinoma |
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| Non-Alcoholic Steatohepatitis |
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| Retinal Cancer |
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| Lymphatic System Disease |
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| Malignant Astrocytoma |
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| Respiratory System Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Arteries, Anomalies Of |
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| Prostate Disease |
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| Nasopharyngeal Carcinoma |
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| Sensory System Disease |
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| Retinal Disease |
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| Bone Cancer |
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| Bone Inflammation Disease |
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| Ocular Cancer |
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| Pre-Eclampsia |
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| Bone Marrow Cancer |
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| Pulmonary Blastoma |
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| Immune System Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Esophageal Disease |
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| Breast Disease |
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| Gallbladder Cancer |
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| Oral Cavity Cancer |
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| Colorectal Cancer |
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| Connective Tissue Disease |
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| Inherited Metabolic Disorder |
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| Rectum Cancer |
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| Bone Disease |
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| Central Nervous System Disease |
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| Cell Type Benign Neoplasm |
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| Hematologic Cancer |
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| Esophageal Cancer |
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| Pancreatic Ductal Adenocarcinoma |
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| Interstitial Lung Disease |
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| Autoimmune Disease Of Musculoskeletal System |
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| Mouth Disease |
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| Lipid Storage Disease |
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| Brain Cancer |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Germ Cell Cancer |
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| Eye Disease |
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| Brittle Bone Disorder |
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| Lymphoma, Non-Hodgkin, Familial |
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| Nervous System Disease |
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| Cardiovascular System Disease |
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| Diffuse Large B-Cell Lymphoma |
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| Hypertension, Essential |
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| Oral Squamous Cell Carcinoma |
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| Interstitial Lung Disease 2 |
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| Ewing Sarcoma |
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| Lipoprotein Quantitative Trait Locus |
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| Lung Cancer Susceptibility 3 |
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| Leukemia, Chronic Lymphocytic |
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| Breast Cancer |
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| Leukemia, Acute Lymphoblastic |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Type 2 Diabetes Mellitus |
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| Dilated Cardiomyopathy |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR214 | MGD | MGI:2676890 |
| Rattus norvegicus | MIR214 | RGD | RGD:2325548 |