CLEC12B - C-type lectin domain family 12 member B Gene

Homo sapiens

Also known as UNQ5782

Gene ID: 387837 | Gene type: protein coding

About CLEC12B

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,006,209-10,018,800 (from NCBI)

This gene has 5 transcripts (splice variants), 351 orthologues and 23 paralogues. Biased expression in testis (RPKM 8.0), skin (RPKM 1.6) and 1 other tissue.

Summary

Enables protein Phosphatase binding activity and signaling receptor inhibitor activity. Involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Located in external side of plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CLEC12B Products(5)

mRNA	Protein	Name
NM_001129998.3	NP_001123470.1	C-type lectin domain family 12 member B isoform 1
NM_001319241.1	NP_001306170.1	C-type lectin domain family 12 member B isoform 3
NM_001319242.1	NP_001306171.1	C-type lectin domain family 12 member B isoform 4
NM_001387138.1	NP_001374067.1	C-type lectin domain family 12 member B isoform 5
NM_205852.3	NP_995324.2	C-type lectin domain family 12 member B isoform 2

CLEC12B Protein Structure

Ly49

Lectin_C

0
100
200
276 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 12 member B

macrophage antigen h

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02782	CLEC12B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLEC12B	MGD	MGI:1918433
Macaca mulatta	CLEC12B	VGNC	VGNC:71378
Felis catus	CLEC12B	VGNC	VGNC:60942
Rattus norvegicus	CLEC12B	RGD	RGD:1560487
Canis familiaris	CLEC12B	VGNC	VGNC:39326
Bos taurus	CLEC12B	VGNC	VGNC:27424

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