CEACAM16 - CEA cell adhesion molecule 16, tectorial membrane component Gene

Homo sapiens

Also known as CEAL2; DFNA4B; DFNB113

Gene ID: 388551 | Gene type: protein coding

About CEACAM16

Cytogenetic location: 19q13.31-q13.32 Genomic coordinates (GRCh38): 19:44,699,151-44,710,718 (from NCBI)

This gene has 2 transcripts (splice variants), 495 orthologues, 24 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

CEACAM16 Products(1)

mRNA	Protein	Name
NM_001039213.4	NP_001034302.2	carcinoembryonic antigen-related cell adhesion molecule 16 precursor

CEACAM16 Protein Structure

V-set

Ig_2

V-set

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

carcinoembryonic antigen-related cell adhesion molecule 16

carcinoembryonic antigen like-2 protein

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 4b

DFNA4B	Autosomal Dominant Nonsyndromic Deafness 4b
Autosomal Dominant Deafness 4b	Deafness, Autosomal Dominant, 4b
Deafness, Autosomal Dominant, Type 4b

Deafness, Autosomal Recessive 113

DFNB113	Autosomal Recessive Nonsyndromic Deafness 113
Autosomal Recessive Deafness 113	Deafness, Autosomal Recessive, 113

Non-Syndromic Genetic Deafness

Nonsyndromic Genetic Hearing Loss	Isolated Genetic Deafness
Isolated Genetic Hearing Loss	Non-Syndromic Genetic Hearing Loss

Nonsyndromic Hearing Loss

Nonsyndromic Deafness	Nonsyndromic Hearing Impairment
Nonsyndromic Hearing Loss And Deafness	Deafness, Nonsyndromic
Isolated Deafness

Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Autosomal Dominant Isolated Neurosensory Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Isolated Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna	Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna
Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Ear Malformation

Cup Ear

Deafness, Autosomal Dominant 64

DFNA64	Autosomal Dominant Nonsyndromic Deafness 64
Autosomal Dominant Deafness 64	Deafness, Autosomal Dominant, 64
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64
Deafness, Autosomal Dominant, Type 64

Deafness, Autosomal Recessive 79

DFNB79	Autosomal Recessive Nonsyndromic Deafness 79
Autosomal Recessive Deafness 79	Deafness, Autosomal Recessive, 79
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 79	Deafness, Autosomal Recessive, Type 79

Deafness, Autosomal Dominant 58

DFNA58	Autosomal Dominant Nonsyndromic Deafness 58
Autosomal Dominant Deafness 58

Deafness, Autosomal Dominant 3a

DFNA3A	Autosomal Dominant Nonsyndromic Deafness 3a
Autosomal Dominant Deafness 3a	Deafness, Autosomal Dominant, 3a
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 3a	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 3a
Deafness, Autosomal Dominant, Type 3a

Deafness, Autosomal Dominant 2a

DFNA2A	Autosomal Dominant Nonsyndromic Deafness 2a
Autosomal Dominant Deafness 2a	Deafness, Autosomal Dominant, 2a
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 2a	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 2a
Deafness, Autosomal Dominant, Type 2a

Deafness, Autosomal Recessive 22

DFNB22	Autosomal Recessive Nonsyndromic Deafness 22
Autosomal Recessive Deafness 22	Deafness, Autosomal Recessive, 22
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 22	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 22

Deafness, Autosomal Recessive 61

DFNB61	Autosomal Recessive Nonsyndromic Deafness 61
Autosomal Recessive Deafness 61	Deafness, Autosomal Recessive, 61
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61
Deafness, Autosomal Recessive, Type 61

Rare Genetic Deafness

Rare Genetic Hearing Loss

Deafness, Autosomal Recessive 84b

DFNB84B	Autosomal Recessive Nonsyndromic Deafness 84b
Autosomal Recessive Deafness 84b	Deafness, Autosomal Recessive, 84b
Deafness, Autosomal Recessive, Type 84b

Deafness, Autosomal Dominant 3b

DFNA3B	Autosomal Dominant Nonsyndromic Deafness 3b
Autosomal Dominant Deafness 3b	Deafness, Autosomal Dominant, 3b
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 3b	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 3b
Deafness, Autosomal Dominant, Type 3b

Deafness, Autosomal Recessive 21

DFNB21	Autosomal Recessive Nonsyndromic Deafness 21
Autosomal Recessive Deafness 21	Deafness, Autosomal Recessive, 21
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 21	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 21
Deafness, Autosomal Recessive, Type 21

Deafness, Autosomal Recessive 18b

DFNB18B	Autosomal Recessive Nonsyndromic Deafness 18b
Autosomal Recessive Deafness 18b	Deafness, Autosomal Recessive, 18b
Deafness, Autosomal Recessive, Type 18b

Usher Syndrome, Type Ic

USH1C	Usher Syndrome Type 1c
Usher Syndrome, Type 1c	Usher Syndrome Type I Acadian Variety
Usher Syndrome Type Ic	Usher Syndrome, Type I, Acadian Variety
Usher Syndrome 1c	Acadian Usher Syndrome
Usher'S Syndrome Type 1c

Deafness, Autosomal Recessive 28

DFNB28	Autosomal Recessive Nonsyndromic Deafness 28
Autosomal Recessive Deafness 28	Deafness, Autosomal Recessive, 28
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 28	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 28
Deafness, Autosomal Recessive, Type 28

Deafness, Autosomal Recessive 42

DFNB42	Autosomal Recessive Nonsyndromic Deafness 42
Autosomal Recessive Deafness 42	Deafness, Autosomal Recessive, 42
Congenital Neurosensory Deafness Autosomal Recessive 42	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 42
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 42	Deafness, Autosomal Recessive, Type 42

Deafness, Autosomal Recessive 1b

DFNB1B	Autosomal Recessive Nonsyndromic Deafness 1b
Autosomal Recessive Deafness 1b	Deafness, Autosomal Recessive, 1b
Deafness Digenic Gjb2/Gjb6	Deafness Neurosensory Autosomal Recessive 1
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 1	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 1
Nsrd1	Deafness, Autosomal Recessive, Type 1b

Deafness, Autosomal Recessive 12

DFNB12	Deafness, Autosomal Recessive 12, Modifier Of
Autosomal Recessive Nonsyndromic Deafness 12	Autosomal Recessive Deafness 12
Deafness, Autosomal Recessive, 12	Congenital Neurosensory Deafness Autosomal Recessive 12
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12
Deafness, Autosomal Recessive, Type 12

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome	Wzs
Pierre Robin Syndrome With Fetal Chondrodysplasia	OSMEDA
Weissenbacher-Zweymüller Syndrome	Heterozygous Osmed
Stickler Syndrome, Type 3	Osmed, Heterozygous
Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly	Stickler Syndrome, Type Iii, Formerly
Stl3, Formerly	Piere-Robin Syndrome
Pierre Robin Malformation	Heterozygous Otospondylomegaepiphyseal Dysplasia
Autosomal Dominant Otospondylomegaepiphyseal Dysplasia	Ad Osmed
Stickler Syndrome Type 3	Stickler Syndrome, Non-Ocular Type
Stickler-Like Syndrome	Stickler Syndrome 3
Stickler Syndrome Non-Ocular Type	Stickler Syndrome Type Iii
Stl3	Weissenbacher-Zweymueller Syndrome
Stickler Syndrome, Type Iii	Pierre Robin Syndrome
Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02436	CEACAM16 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CEACAM16	VGNC	VGNC:108495
Bos taurus	CEACAM16	VGNC	VGNC:27161
Mus musculus	CEACAM16	MGD	MGI:2685615
Rattus norvegicus	CEACAM16	RGD	RGD:1306386
Canis familiaris	CEACAM16	VGNC	VGNC:39087

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