2. Gene
  3. HAPLN4 - hyaluronan and proteoglycan link protein 4 Gene

HAPLN4 - hyaluronan and proteoglycan link protein 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BRAL2

Gene ID: 404037 | Gene type: protein coding

About HAPLN4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,254,756-19,262,804 (from NCBI)

This gene has 2 transcripts (splice variants), 188 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 9.9), duodenum (RPKM 7.8) and 4 other tissues.

Summary

Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

HAPLN4 Products(1)

mRNA Protein Name
NM_023002.3 NP_075378.1 hyaluronan and proteoglycan link protein 4 precursor

HAPLN4 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (48 - 151)

Xlink

Xlink: Extracellular link domain (162 - 267)

Xlink

Xlink: Extracellular link domain (274 - 364)

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  • 402 a.a.
Protein Preferred Names Protein Names

hyaluronan and proteoglycan link protein 4

brain link protein 2

Related Diseases

Diseases Alias
Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1
Tremor, Hereditary Essential, 4

ETM4

Essential Tremor 4

Essential Tremor, Hereditary, 4

Hereditary Essential Tremor 4

Tremor, Hereditary Essential 4

Tremor, Hereditary Essential, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06004 HAPLN4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HAPLN4 VGNC VGNC:52237
Rattus norvegicus HAPLN4 RGD RGD:1308408
Macaca mulatta HAPLN4 VGNC VGNC:73261
Felis catus HAPLN4 VGNC VGNC:62752
Mus musculus HAPLN4 MGD MGI:2679531
Canis familiaris HAPLN4 VGNC VGNC:41595