Ano7 - anoctamin 7 Gene

Also Known as Ngep; Ngep-L; Pcanap5; Tmem16g

Species: Mus musculus

Gene Type: protein coding
Gene ID: 404545

Summary

This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate Cancer Immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]

Ano7 Products (2)

mRNA Protein Name
NM_001271884.1 NP_001258813.1 anoctamin-7 isoform 2
NM_207031.2 NP_996914.1 anoctamin-7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
23532839 MGI
enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
23532839 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium activated galactosylceramide scrambling IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within calcium activated phosphatidylcholine scrambling IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within calcium activated phosphatidylserine scrambling IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
23532839 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
20056604 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anoctamin-7

  • prostate cancer associated protein 5

  • transmembrane protein 16g

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00747 ANO7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ano7 NCBI NCBI:50636