Iqsec3 - IQ motif and Sec7 domain ArfGEF 3 Gene

Also Known as sag

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 404781

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in activation of GTPase activity; regulation of small GTPase mediated signal transduction; and synapse organization. Is active in GABA-ergic synapse. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Apr 2022]

Iqsec3 Products (1)

mRNA	Protein	Name
NM_207617.1	NP_997500.1	IQ motif and SEC7 domain-containing protein 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	21198641	RGD
involved in postsynapse organization	IDA IDA: Inferred from direct assay	27002143	RGD
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	27002143	RGD
involved in regulation of small GTPase mediated signal transduction	IDA IDA: Inferred from direct assay	21198641	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	27002143	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	27002143	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
IQ motif and SEC7 domain-containing protein 3	IQ motif and Sec7 domain 3 potential synaptic guanine nucleotide exchange factor for Arf synArfGEF synArfGEF-Po

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06890	IQSEC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Iqsec3	NCBI	NCBI:440073