MIR125A - microRNA 125a Gene
Also Known as MIRN125A; mir-125a; miRNA125A
Species: Homo sapiens
About MIR125A
This gene has 1 transcript (splice variant), 73 orthologues and 7 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
30089723 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
20190813 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
27252357 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Medulloblastoma |
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| Lung Cancer |
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| Breast Cancer |
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| Ovarian Cancer |
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| Vascular Disease |
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| Endometriosis |
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| Ovarian Serous Carcinoma |
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| Pancreatitis, Hereditary |
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| Leukemia, Acute Lymphoblastic |
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| Myeloma, Multiple |
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| Neuroblastoma |
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| Type 2 Diabetes Mellitus |
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| Pancreatic Cancer |
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| Leukemia, Acute Myeloid |
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| Prostate Cancer |
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| Colorectal Cancer |
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| Verrucous Carcinoma |
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| Hepatocellular Carcinoma |
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| Lipomatosis, Multiple Symmetric |
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| Pleuropulmonary Blastoma |
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| Autoimmune Disease Of Musculoskeletal System |
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| Thoracic Cancer |
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| Endocrine System Disease |
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| Respiratory System Cancer |
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| Bone Marrow Cancer |
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| Larynx Cancer |
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| Endocrine Gland Cancer |
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| Immune System Disease |
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| Colonic Disease |
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| Respiratory System Disease |
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| Large Intestine Cancer |
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| Pancreas Disease |
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| Gastrointestinal System Cancer |
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| Gastrointestinal System Disease |
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| Cerebral Arterial Disease |
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| Periodontitis |
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| Retinal Cancer |
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| Microscopic Polyangiitis |
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| Connective Tissue Cancer |
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| Stomach Disease |
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| Upper Respiratory Tract Disease |
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| Pulmonary Blastoma |
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| Male Reproductive Organ Cancer |
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| Bone Inflammation Disease |
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| Intestinal Disease |
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| Spinal Disease |
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| Autoimmune Disease Of Endocrine System |
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| Reproductive System Disease |
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| Central Nervous System Cancer |
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| Lymphatic System Cancer |
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| Female Reproductive System Disease |
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| Male Reproductive System Disease |
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| Oral Cavity Cancer |
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| Cervix Disease |
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| Lymphatic System Disease |
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| Pharynx Cancer |
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| Leukocyte Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Bile Duct Cancer |
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| Arteries, Anomalies Of |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Autoimmune Disease Of Central Nervous System |
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| Urinary System Disease |
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| Bladder Disease |
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| Nasopharyngeal Disease |
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| Malignant Astrocytoma |
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| Pleural Disease |
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| Uterine Anomalies |
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| Ovary Epithelial Cancer |
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| Integumentary System Disease |
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| Lipomatosis |
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| Laryngeal Disease |
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| Ocular Cancer |
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| Infratentorial Cancer |
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| Sensory System Disease |
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| Inherited Metabolic Disorder |
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| Autonomic Nervous System Neoplasm |
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| Bile Duct Adenocarcinoma |
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| Nasopharyngeal Carcinoma |
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| Thymus Gland Disease |
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| Biliary Tract Cancer |
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| Estrogen-Receptor Positive Breast Cancer |
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| Rectum Cancer |
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| Central Nervous System Disease |
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| Peripheral Nervous System Neoplasm |
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| Breast Disease |
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| Esophageal Disease |
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| Thymus Cancer |
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| Prostate Disease |
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| Carbohydrate Metabolic Disorder |
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| Retinal Disease |
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| Glucose Metabolism Disease |
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| Bone Cancer |
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| Ovarian Disease |
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| Head And Neck Cancer |
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| Gallbladder Disease |
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| Cell Type Benign Neoplasm |
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| Listeriosis |
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| Cervical Cancer |
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| Mature B-Cell Neoplasm |
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| Fragile X Syndrome |
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| Plasma Cell Leukemia |
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| Bile Duct Disease |
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| Secondary Progressive Multiple Sclerosis |
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| Thyroid Gland Cancer |
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| Primary Bacterial Infectious Disease |
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| Biliary Tract Disease |
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| Tongue Disease |
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| Ectopic Pregnancy |
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| Disease By Infectious Agent |
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| Demyelinating Disease |
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| Hematologic Cancer |
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| Human Papillomavirus Infectious Disease |
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| Multiple Sclerosis |
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| Mouth Disease |
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| Disease Of Mental Health |
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| Hashimoto Thyroiditis |
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| Legionellosis |
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| Connective Tissue Disease |
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| Cerebrovascular Disease |
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| Acquired Metabolic Disease |
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| Microinvasive Gastric Cancer |
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| Tongue Squamous Cell Carcinoma |
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| Overnutrition |
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| Brain Cancer |
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| Chromosomal Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Spinal Cord Disease |
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| Bone Sarcoma |
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| Ischemic Bone Disease |
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| Gallbladder Cancer |
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| Pancreatic Ductal Adenocarcinoma |
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| Bone Disease |
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| Bone Resorption Disease |
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| Phenylketonuria |
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| Lymphoma, Non-Hodgkin, Familial |
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| Retinitis Pigmentosa 11 |
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| Nervous System Disease |
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| Peripheral Nervous System Disease |
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| Uveal Disease |
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| Thyroid Gland Follicular Carcinoma |
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| Esophageal Cancer |
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| Immune Deficiency Disease |
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| Oral Squamous Cell Carcinoma |
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| Eye Disease |
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| Systemic Lupus Erythematosus |
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| Cardiovascular System Disease |
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| Bone Remodeling Disease |
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| Melanoma, Uveal |
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| Thyroid Gland Disease |
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| Plasma Cell Neoplasm |
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| Gastric Cancer |
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| Diffuse Large B-Cell Lymphoma |
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| Wilms Tumor 1 |
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| Hypertension, Essential |
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| Leukemia, Chronic Myeloid |
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| Lung Squamous Cell Carcinoma |
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| Skin Disease |
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| Lung Cancer Susceptibility 3 |
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| Crohn'S Disease |
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| Physical Disorder |
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| Leukemia, Chronic Lymphocytic |
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| Squamous Cell Carcinoma, Head And Neck |
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| Lipoprotein Quantitative Trait Locus |
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| Diamond-Blackfan Anemia 1 |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Alzheimer Disease, Familial, 1 |
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| Amyotrophic Lateral Sclerosis 1 |
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| Parkinson Disease, Late-Onset |
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| Retinitis Pigmentosa |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR125A | RGD | RGD:2325387 |
| Mus musculus | MIR125A | MGD | MGI:2676809 |