MIR141 - microRNA 141 Gene
Also Known as MIRN141; mir-141
Species: Homo sapiens
About MIR141
This gene has 1 transcript (splice variant).
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
22479552 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
15131085 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
21224847 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cholangiocarcinoma |
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| Renal Cell Carcinoma, Nonpapillary |
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| Lung Cancer |
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| Gastric Cancer |
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| Colorectal Cancer |
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| Breast Cancer |
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| Ovarian Serous Carcinoma |
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| Kidney Disease |
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| Endometriosis |
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| Kidney Cancer |
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| Squamous Cell Carcinoma, Head And Neck |
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| Endometriosis Of Ovary |
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| Psoriasis |
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| Leukemia, Chronic Lymphocytic |
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| Pancreatic Ductal Adenocarcinoma |
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| Ovarian Cancer |
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| Prostate Cancer |
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| Melanoma |
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| Reproductive System Disease |
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| Female Reproductive System Disease |
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| Hepatocellular Carcinoma |
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| Ovarian Disease |
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| Male Reproductive Organ Cancer |
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| Ovary Epithelial Cancer |
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| Male Reproductive System Disease |
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| Cervix Carcinoma |
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| Uterine Anomalies |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Renal Hypertension |
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| Endocrine System Disease |
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| Bladder Disease |
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| Endometrial Disease |
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| Larynx Cancer |
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| Nasopharyngeal Disease |
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| Cervix Disease |
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| Prostate Disease |
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| Pharynx Cancer |
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| Nasopharyngeal Carcinoma |
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| Urinary System Disease |
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| Thoracic Cancer |
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| T-Cell Prolymphocytic Leukemia |
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| Large Intestine Cancer |
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| Upper Respiratory Tract Disease |
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| Endocrine Gland Cancer |
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| Intestinal Disease |
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| Respiratory System Cancer |
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| Colonic Disease |
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| Gastrointestinal System Cancer |
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| Pancreas Disease |
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| Respiratory System Disease |
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| Laryngeal Disease |
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| Stomach Disease |
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| Gastrointestinal System Disease |
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| Cervical Cancer |
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| Breast Disease |
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| Head And Neck Cancer |
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| Endometrial Cancer |
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| Lymphatic System Cancer |
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| Immune System Disease |
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| Arteries, Anomalies Of |
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| Connective Tissue Cancer |
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| Lymphatic System Disease |
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| Cervical Squamous Cell Carcinoma |
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| Oral Cavity Cancer |
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| Malignant Astrocytoma |
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| Carbohydrate Metabolic Disorder |
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| Spinal Disease |
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| Glucose Metabolism Disease |
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| Bone Cancer |
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| Central Nervous System Cancer |
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| Inherited Metabolic Disorder |
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| Hematologic Cancer |
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| Connective Tissue Disease |
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| Peripheral Nervous System Disease |
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| Oral Squamous Cell Carcinoma |
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| Lung Cancer Susceptibility 3 |
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| Hypertension, Essential |
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| Nervous System Disease |
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| Leukemia, Chronic Myeloid |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR141 | RGD | RGD:2325407 |
| Mus musculus | MIR141 | MGD | MGI:2676826 |