MIR200A - microRNA 200a Gene
Also Known as MIRN200A; mir-200a
Species: Homo sapiens
About MIR200A
This gene has 1 transcript (splice variant), 91 orthologues and 2 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
21698760 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in miRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
21698760 | GOA |
| involved in miRNA-mediated post-transcriptional gene silencing |
IGI
IGI: Inferred from genetic interaction
|
28008308 | GOA |
| involved in positive regulation of blood vessel endothelial cell migration |
IMP
IMP: Inferred from mutant phenotype
|
21698760 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Meningioma, Familial |
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| Ovarian Cancer |
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| Lung Cancer |
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| Breast Cancer |
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| Kidney Disease |
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| Ovarian Serous Carcinoma |
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| Non-Alcoholic Fatty Liver Disease |
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| Lymphoma, Hodgkin, Classic |
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| Endometriosis |
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| Psoriasis |
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| Squamous Cell Carcinoma, Head And Neck |
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| Melanoma |
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| Benign Ileal Neoplasm |
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| Hepatocellular Carcinoma |
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| Female Reproductive System Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Ovary Epithelial Cancer |
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| Reproductive System Disease |
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| Uterine Anomalies |
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| Colon Adenoma |
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| Renal Hypertension |
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| Cervix Disease |
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| Endometrial Adenocarcinoma |
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| Thoracic Cancer |
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| Large Intestine Cancer |
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| Colonic Disease |
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| Cervix Carcinoma |
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| Endocrine System Disease |
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| Intestinal Disease |
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| Bladder Disease |
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| Gastrointestinal System Cancer |
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| Bladder Cancer |
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| Ovarian Disease |
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| Lipomatosis, Multiple Symmetric |
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| Gastrointestinal System Disease |
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| Obstructive Nephropathy |
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| Respiratory System Cancer |
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| Urinary System Disease |
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| Endometrial Disease |
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| Endocrine Gland Cancer |
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| Cell Type Benign Neoplasm |
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| Male Reproductive Organ Cancer |
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| Male Reproductive System Disease |
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| Pleural Cancer |
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| Esophageal Disease |
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| Intestinal Benign Neoplasm |
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| Colonic Benign Neoplasm |
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| Esophageal Cancer |
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| Cervical Cancer |
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| Respiratory System Disease |
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| Breast Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Gastrointestinal System Benign Neoplasm |
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| Stomach Disease |
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| Colorectal Cancer |
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| Pancreas Disease |
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| Chromophobe Renal Cell Carcinoma |
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| Oral Cavity Cancer |
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| Central Nervous System Cancer |
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| Endometrial Cancer |
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| Pleural Disease |
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| Prostate Disease |
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| Head And Neck Cancer |
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| Endometritis |
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| Lymphangioma |
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| Spinal Cord Disease |
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| Rectum Cancer |
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| Thyroid Gland Anaplastic Carcinoma |
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| Cardiovascular Organ Benign Neoplasm |
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| Inherited Metabolic Disorder |
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| Malignant Astrocytoma |
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| Immune System Disease |
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| Ocular Cancer |
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| Retinal Cancer |
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| Connective Tissue Cancer |
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| Central Nervous System Disease |
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| Skin Melanoma |
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| Spinal Disease |
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| Carbohydrate Metabolic Disorder |
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| Glucose Metabolism Disease |
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| Oral Squamous Cell Carcinoma |
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| Melanoma, Uveal |
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| Nervous System Disease |
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| Lung Cancer Susceptibility 3 |
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| Connective Tissue Disease |
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| Eye Disease |
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| Lymphoma, Non-Hodgkin, Familial |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR200A | MGD | MGI:2676874 |
| Rattus norvegicus | MIR200A | RGD | RGD:2325426 |