MIR205 - microRNA 205 Gene
Also Known as MIRN205; mir-205
Species: Homo sapiens
About MIR205
This gene has 1 transcript (splice variant) and 130 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
22578566 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
22578566 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
19665999 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Head And Neck Cancer |
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| Squamous Cell Carcinoma |
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| Prostate Cancer |
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| Lung Cancer |
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| Melanoma |
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| Breast Cancer |
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| Squamous Cell Carcinoma, Head And Neck |
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| Esophageal Cancer |
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| Pancreatic Ductal Adenocarcinoma |
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| Bladder Cancer |
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| Pancreatic Cancer |
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| Hepatocellular Carcinoma |
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| Nasopharyngeal Disease |
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| Thymus Gland Disease |
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| Pharynx Cancer |
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| Thymus Cancer |
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| Upper Respiratory Tract Disease |
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| Ovary Epithelial Cancer |
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| Respiratory System Cancer |
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| Thoracic Cancer |
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| Male Reproductive Organ Cancer |
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| Male Reproductive System Disease |
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| Nasopharyngeal Carcinoma |
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| Female Reproductive System Disease |
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| Reproductive System Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Bladder Disease |
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| Oral Cavity Cancer |
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| Respiratory System Disease |
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| Endometriosis |
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| Endocrine System Disease |
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| Prostate Disease |
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| Gastrointestinal System Cancer |
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| Breast Disease |
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| Uterine Anomalies |
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| Stomach Disease |
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| Lip Cancer |
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| Ovarian Disease |
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| Malignant Astrocytoma |
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| Urinary System Disease |
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| Spinal Disease |
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| Gastrointestinal System Disease |
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| Large Intestine Cancer |
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| Cervical Cancer |
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| Low Grade Glioma |
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| Central Nervous System Cancer |
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| Aortic Aneurysm, Familial Abdominal, 1 |
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| Cervix Disease |
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| Intestinal Disease |
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| Connective Tissue Cancer |
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| Cell Type Benign Neoplasm |
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| Central Nervous System Benign Neoplasm |
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| Colonic Disease |
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| Endocrine Gland Cancer |
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| Bone Cancer |
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| Aortic Disease |
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| Mouth Disease |
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| Spinal Cord Disease |
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| Lymphatic System Cancer |
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| Colorectal Cancer |
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| Lymphatic System Disease |
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| Pancreas Disease |
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| Immune System Disease |
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| Oral Squamous Cell Carcinoma |
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| Connective Tissue Disease |
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| Ovarian Cancer |
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| Nervous System Disease |
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| Lung Cancer Susceptibility 3 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR205 | MGD | MGI:2676880 |
| Rattus norvegicus | MIR205 | RGD | RGD:2325377 |