MIR25 - microRNA 25 Gene
Also Known as MIRN25; miR-25; hsa-mir-25
Species: Homo sapiens
About MIR25
This gene has 1 transcript (splice variant), 87 orthologues and 2 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
Related Diseases
| Diseases | Alias | |
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| Brain Cancer |
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| Myeloma, Multiple |
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| Gastric Cancer |
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| Hepatocellular Carcinoma |
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| Glioblastoma |
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| Pancreatic Cancer |
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| Glioma |
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| Prostate Cancer |
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| Colorectal Cancer |
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| Childhood Ependymoma |
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| Coronary Stenosis |
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| Atypical Teratoid Rhabdoid Tumor |
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| Infratentorial Cancer |
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| Colonic Disease |
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| Retinitis Pigmentosa 11 |
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| Large Intestine Cancer |
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| Respiratory System Cancer |
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| Male Reproductive Organ Cancer |
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| Stomach Disease |
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| Male Reproductive System Disease |
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| Gastrointestinal System Cancer |
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| Intestinal Disease |
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| Biliary Tract Cancer |
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| Lung Cancer |
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| Thoracic Cancer |
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| Gastrointestinal System Disease |
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| Respiratory System Disease |
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| Prostate Disease |
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| Retinal Disease |
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| Cervix Disease |
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| Endocrine Gland Cancer |
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| Cervical Cancer |
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| Osteoporosis |
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| Endocrine System Disease |
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| Arteries, Anomalies Of |
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| Retinal Cancer |
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| Central Nervous System Cancer |
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| Sensory System Disease |
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| Reproductive System Disease |
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| Ovary Epithelial Cancer |
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| Female Reproductive System Disease |
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| Head And Neck Cancer |
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| Renal Cell Carcinoma, Nonpapillary |
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| Urinary System Disease |
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| Oral Cavity Cancer |
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| Bone Resorption Disease |
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| Uterine Anomalies |
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| Breast Disease |
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| Inherited Metabolic Disorder |
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| Ocular Cancer |
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| Lymphatic System Cancer |
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| Pancreas Disease |
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| Lymphatic System Disease |
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| Connective Tissue Cancer |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Malignant Astrocytoma |
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| Phenylketonuria |
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| Central Nervous System Disease |
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| Aortic Dissection |
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| Bone Remodeling Disease |
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| Spinal Disease |
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| Hematologic Cancer |
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| Nervous System Disease |
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| Eye Disease |
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| Connective Tissue Disease |
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| Cardiovascular System Disease |
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| Leukemia, Acute Myeloid |
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| Lung Cancer Susceptibility 3 |
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| Skin Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR25 | RGD | RGD:2325594 |
| Mus musculus | MIR25 | MGD | MGI:3619266 |