MIR30A - microRNA 30a Gene
Also Known as MIRN30A; mir-30a
Species: Homo sapiens
About MIR30A
This gene has 1 transcript (splice variant), 74 orthologues and 5 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is one of five members of the miR-30 family of highly conserved miRNAs and participates in many cellular processes. It has additionally been implicated in the development of several types of Cancer. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2017]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
31678166 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
23086751 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in miRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
23960241 | GOA |
| involved in miRNA-mediated post-transcriptional gene silencing |
IMP
IMP: Inferred from mutant phenotype
|
23086751 | GOA |
| involved in positive regulation of angiogenesis |
IDA
IDA: Inferred from direct assay
|
23960241 | GOA |
| involved in positive regulation of blood vessel endothelial cell migration |
IDA
IDA: Inferred from direct assay
|
23960241 | GOA |
| involved in transforming growth factor beta receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
23960241 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Glomerular Disease |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Non-Alcoholic Fatty Liver Disease |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Polymyositis |
|
|
| Dermatomyositis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Leiomyoma, Uterine |
|
|
| Muscular Dystrophy, Duchenne Type |
|
|
| Nemaline Myopathy |
|
|
| Leukemia, Acute Myeloid |
|
|
| Schizophrenia |
|
|
| Ovarian Cancer |
|
|
| Prostate Cancer |
|
|
| Lung Cancer |
|
|
| Colorectal Cancer |
|
|
| Ovary Epithelial Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Breast Cancer |
|
|
| Respiratory System Cancer |
|
|
| Papillary Serous Adenocarcinoma |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Thoracic Cancer |
|
|
| Endocrine System Disease |
|
|
| Respiratory System Disease |
|
|
| Stomach Disease |
|
|
| Malignant Exocrine Pancreas Neoplasm |
|
|
| Female Reproductive System Disease |
|
|
| Systemic Scleroderma |
|
|
| Papillary Adenocarcinoma |
|
|
| Reproductive System Disease |
|
|
| Endocrine Gland Cancer |
|
|
| Urinary System Disease |
|
|
| Gastrointestinal System Cancer |
|
|
| Nasopharyngeal Disease |
|
|
| Serous Cystadenocarcinoma |
|
|
| Male Reproductive Organ Cancer |
|
|
| Gastrointestinal System Disease |
|
|
| Large Intestine Cancer |
|
|
| Ovary Adenocarcinoma |
|
|
| Male Reproductive System Disease |
|
|
| Pharynx Cancer |
|
|
| Skin Carcinoma |
|
|
| Colonic Disease |
|
|
| Bile Duct Cancer |
|
|
| Tongue Disease |
|
|
| Intestinal Disease |
|
|
| Retinal Vascular Disease |
|
|
| Carbohydrate Metabolic Disorder |
|
|
| Oral Cavity Cancer |
|
|
| Pancreas Disease |
|
|
| Inherited Metabolic Disorder |
|
|
| Gallbladder Disease |
|
|
| Tongue Carcinoma |
|
|
| Bladder Disease |
|
|
| Uterine Anomalies |
|
|
| Upper Respiratory Tract Disease |
|
|
| Bile Duct Adenocarcinoma |
|
|
| Glucose Metabolism Disease |
|
|
| Connective Tissue Cancer |
|
|
| Gallbladder Cancer |
|
|
| Central Nervous System Cancer |
|
|
| Sensory System Disease |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Immune System Disease |
|
|
| Ovarian Disease |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Lymphatic System Cancer |
|
|
| Retinal Disease |
|
|
| Esophageal Disease |
|
|
| Lymphatic System Disease |
|
|
| Breast Disease |
|
|
| Liver Disease |
|
|
| Malignant Astrocytoma |
|
|
| Arteries, Anomalies Of |
|
|
| Bile Duct Disease |
|
|
| Prostate Disease |
|
|
| Spinal Disease |
|
|
| Biliary Tract Cancer |
|
|
| Bone Inflammation Disease |
|
|
| Bone Marrow Cancer |
|
|
| Biliary Tract Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Head And Neck Cancer |
|
|
| Autonomic Nervous System Neoplasm |
|
|
| Cystic Echinococcosis |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Esophageal Cancer |
|
|
| Tongue Squamous Cell Carcinoma |
|
|
| Breast Carcinoma In Situ |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Central Nervous System Disease |
|
|
| Cervix Disease |
|
|
| Pre-Eclampsia |
|
|
| Cystadenocarcinoma |
|
|
| In Situ Carcinoma |
|
|
| Microvascular Complications Of Diabetes 5 |
|
|
| Bone Cancer |
|
|
| Purulent Acute Otitis Media |
|
|
| Ductal Carcinoma In Situ |
|
|
| Merkel Cell Carcinoma |
|
|
| Myocardial Infarction |
|
|
| Large Cell Carcinoma |
|
|
| Pre-Malignant Neoplasm |
|
|
| Cervical Cancer |
|
|
| Cervix Carcinoma |
|
|
| Integumentary System Disease |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Lung Squamous Cell Carcinoma |
|
|
| Pancreatic Ductal Adenocarcinoma |
|
|
| Disease By Infectious Agent |
|
|
| Rectum Cancer |
|
|
| Retinal Cancer |
|
|
| Cell Type Benign Neoplasm |
|
|
| Osteoporosis |
|
|
| Hematologic Cancer |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Kidney Cancer |
|
|
| Ocular Cancer |
|
|
| Lung Disease |
|
|
| Overnutrition |
|
|
| Intrinsic Cardiomyopathy |
|
|
| Gestational Trophoblastic Neoplasm |
|
|
| Iga Glomerulonephritis |
|
|
| Acquired Metabolic Disease |
|
|
| Connective Tissue Disease |
|
|
| Interstitial Lung Disease |
|
|
| Leukocyte Disease |
|
|
| Endometrial Cancer |
|
|
| Phenylketonuria |
|
|
| Laryngeal Disease |
|
|
| Bone Resorption Disease |
|
|
| Bone Disease |
|
|
| Mouth Disease |
|
|
| Cerebrovascular Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Nervous System Disease |
|
|
| Brain Cancer |
|
|
| Cardiovascular System Disease |
|
|
| Pancreatic Cancer |
|
|
| Disease Of Mental Health |
|
|
| Hypertension, Essential |
|
|
| Eye Disease |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Interstitial Lung Disease 2 |
|
|
| Gastric Cancer |
|
|
| Oral Squamous Cell Carcinoma |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Focal Segmental Glomerulosclerosis |
|
|
| Lynch Syndrome |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Skin Disease |
|
|
| Immune Deficiency Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Dilated Cardiomyopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR30A | MGD | MGI:2676907 |
| Rattus norvegicus | MIR30A | RGD | RGD:2325588 |