MAP6 - microtubule associated protein 6 Gene

Also Known as STOP; MTAP6; MAP6-N; N-STOP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4135

About MAP6

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,586,918-75,669,038 (from NCBI)

This gene has 4 transcripts (splice variants), 267 orthologues and 1 paralogue. Biased expression in brain (RPKM 4.6), testis (RPKM 2.8) and 13 other tissues.

Summary

This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MAP6 Products (2)

mRNA	Protein	Name
NM_033063.2	NP_149052.1	microtubule-associated protein 6 isoform 1
NM_207577.1	NP_997460.1	microtubule-associated protein 6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24357581	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	24357581	GOA
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	24357581	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in microtubule	IDA IDA: Inferred from direct assay	17210638	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17210638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP6 Protein Structure

STOP

0
200
400
600
813 a.a.

Protein Preferred Names	Protein Names
microtubule-associated protein 6	CTD-2530H12.7

Related Diseases

Diseases	Alias
Cardia Cancer	Ca Cardia - Stomach Malignant Neoplasm Of Cardia Of Stomach
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Schizophrenia 1	SCZD1 Schizophrenia Susceptibility Locus, Chromosome 5-Related Schizophrenia 1 With Or Without An Affective Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08086	MAP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MAP6	VGNC	VGNC:74640
Canis familiaris	MAP6	VGNC	VGNC:42986
Bos taurus	MAP6	VGNC	VGNC:54448
Mus musculus	MAP6	MGD	MGI:1201690
Felis catus	MAP6	VGNC	VGNC:82020
Rattus norvegicus	MAP6	RGD	RGD:61804