Dnai2 - dynein axonemal intermediate chain 2 Gene

Also Known as Gm728; Dnaic2; b2b3405Clo; C030015H18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 432611

Summary

Predicted to enable dynein heavy chain binding activity; dynein light chain binding activity; and microtubule motor activity. Predicted to be involved in cilium movement; determination of left/right symmetry; and outer dynein arm assembly. Predicted to act upstream of or within cilium assembly. Located in 9+2 motile cilium; axoneme; and external side of plasma membrane. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]

Dnai2 Products (1)

mRNA Protein Name
NM_001034878.3 NP_001030050.2 dynein axonemal intermediate chain 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19052621 MGI
Cellular Component GO Annotation Evidence References Source
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
23525783 MGI
located in axoneme IDA
IDA: Inferred from direct assay
29916806 MGI
located in cilium IDA
IDA: Inferred from direct assay
29916806 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29916806 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
18547164 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal intermediate chain 2

dynein intermediate chain 2, axonemal

  • dynein, axonemal, intermediate polypeptide 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03856 DNAI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnai2 NCBI NCBI:64446