TMEM41B - transmembrane protein 41B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 440026

About TMEM41B

This gene has 7 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 11.2), thyroid (RPKM 10.7) and 25 other tissues.

Summary

Involved in autophagosome assembly. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM41B Products (2)

mRNA Protein Name
NM_001165030.3 NP_001158502.1 transmembrane protein 41B isoform 2
NM_015012.4 NP_055827.1 transmembrane protein 41B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
33850023 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30093494 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
30093494 GOA
involved in intracellular lipid transport IDA
IDA: Inferred from direct assay
34043740 GOA
involved in modulation by host of viral RNA genome replication IDA
IDA: Inferred from direct assay
34043740 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
34043740 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30093494 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
30352685 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM41B Protein Structure

SNARE_assoc

SNARE_assoc: SNARE associated Golgi protein (129 - 248)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

transmembrane protein 41B

  • protein stasimon

Related Diseases

Diseases Alias
Yellow Fever

  • Urban Yellow Fever

  • Jungle Yellow Fever

  • Sylvatic Yellow Fever

  • Yf

  • Yellow Fever, Sylvan

  • Bronze John

  • Yellow Jack

  • Yf- [Yellow Fever]

  • Febris Flava
Alkhurma Hemorrhagic Fever

  • Alkhumra Haemorrhagic Fever
Kyasanur Forest Disease

  • Kfd

  • Monkey Fever

  • Kfd Virus

  • Kyasanur Hemorrhagic Fever

  • Monkey Disease

  • Monkey Diseases

  • Kfd - [ Kyasanur Forest Disease]

  • Monkey Sickness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14723 TMEM41B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20657 Tmem41b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27168 Tmem41b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM41B VGNC VGNC:47580
Felis catus TMEM41B VGNC VGNC:66345
Mus musculus TMEM41B MGD MGI:1289225
Bos taurus TMEM41B VGNC VGNC:36086
Rattus norvegicus TMEM41B RGD RGD:1310870
Macaca mulatta TMEM41B VGNC VGNC:79754
Others TMEM41B NCBI