PIWIL3 - piwi like RNA-mediated gene silencing 3 Gene

Also Known as HIWI3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 440822

About PIWIL3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,719,034-24,774,720 (from NCBI)

This gene has 4 transcripts (splice variants), 174 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

PIWIL3 Products (2)

mRNA	Protein	Name
NM_001008496.3	NP_001008496.2	piwi-like protein 3 isoform 1
NM_001255975.1	NP_001242904.1	piwi-like protein 3 isoform 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28025795	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28025795	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIWIL3 Protein Structure

PAZ

Piwi

0
200
400
600
800
882 a.a.

Protein Preferred Names	Protein Names
piwi-like protein 3	piwi-like 3

Related Diseases

Diseases	Alias
Anal Canal Carcinoma	Anal Canal Cancer Anal Canal And Perianal Gland Carcinoma Carcinoma Of The Anal Canal Carcinoma Of Anal Canal
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10586	PIWIL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown