Arhgef15 - Rho guanine nucleotide exchange factor (GEF) 15 Gene

Mus musculus

Also known as E5; D130071N09; D530030K12Rik

Gene ID: 442801 | Gene type: protein coding

About Arhgef15

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef15 Products(2)

mRNA	Protein	Name
NM_001364772.2	NP_001351701.1	rho guanine nucleotide exchange factor 15 isoform 2
NM_177566.5	NP_808234.2	rho guanine nucleotide exchange factor 15 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	21029865	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21029865	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	21029865	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	28185854	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	28185854	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	22535667	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	21029865	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28185854	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28185854	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	28185854	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	28185854	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 15

ephexin-5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00950	ARHGEF15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgef15	NCBI	NCBI:22899

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