Arhgef15 - Rho guanine nucleotide exchange factor (GEF) 15 Gene

Also Known as E5; D130071N09; D530030K12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 442801

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef15 Products (2)

mRNA Protein Name
NM_001364772.2 NP_001351701.1 rho guanine nucleotide exchange factor 15 isoform 2
NM_177566.5 NP_808234.2 rho guanine nucleotide exchange factor 15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
21029865 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21029865 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of synapse maturation IMP
IMP: Inferred from mutant phenotype
21029865 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
28185854 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
28185854 MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
22535667 MGI
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
21029865 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28185854 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28185854 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
28185854 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
28185854 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 15

  • ephexin-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00950 ARHGEF15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef15 NCBI NCBI:22899