MTIF2 - mitochondrial translational initiation factor 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4528

About MTIF2

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:55,236,595-55,269,248 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and 18 paralogues. Ubiquitous expression in colon (RPKM 8.3), thyroid (RPKM 7.3) and 25 other tissues.

Summary

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]

MTIF2 Products (7)

mRNA Protein Name
NM_001005369.1 NP_001005369.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321001.1 NP_001307930.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321002.1 NP_001307931.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321003.1 NP_001307932.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321004.1 NP_001307933.1 translation initiation factor IF-2, mitochondrial isoform a precursor
NM_001321005.1 NP_001307934.1 translation initiation factor IF-2, mitochondrial isoform b
NM_002453.3 NP_002444.2 translation initiation factor IF-2, mitochondrial isoform a precursor

MTIF2 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (181 - 341)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (369 - 430)

IF-2

IF-2: Translation-initiation factor 2 (510 - 607)

  • 0
  • 200
  • 400
  • 600
  • 727 a.a.
Protein Preferred Names Protein Names

translation initiation factor IF-2, mitochondrial

  • IF-2mt

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 39

  • COXPD39

  • Combined Oxidative Phosphorylation Defect Type 39

  • Gfm2-Related Combined Oxidative Phosphorylation Defect
Combined Oxidative Phosphorylation Deficiency 3

  • Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3

  • COXPD3

  • Encephalomyopathy, Respiratory Failure, And Lactic Acidosis

  • Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis

  • Fatal Mitochondrial Disease Due To Coxpd3

  • Concentric Cardiomyopathy Hypotonia And Lactic Acidosis

  • Encephalomyopathy Respiratory Failure And Lactic Acidosis

  • Encephalomyopathy With Respiratory Failure And Lactic Acidosis

  • Combined Oxidative Phosphorylation Deficiency, Type 3
Combined Oxidative Phosphorylation Deficiency 1

  • Hepatoencephalopathy Due To Combined Oxidative Phosphorylation Defect Type 1

  • COXPD1

  • Early Fatal Progressive Hepatoencephalopathy

  • Hepatoencephalopathy Due To Coxpd1

  • Combined Oxidative Phosphorylation Deficiency, Type 1

  • Hepatoencephalopathy, Early Fatal Progressive

  • Hepatoencephalopathy Early Fatal Progressive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08781 MTIF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22653 Mtif2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MTIF2 RGD RGD:1303046
Mus musculus MTIF2 MGD MGI:1924034
Bos taurus MTIF2 VGNC VGNC:31733
Canis familiaris MTIF2 VGNC VGNC:43475
Macaca mulatta MTIF2 VGNC VGNC:75070
Felis catus MTIF2 VGNC VGNC:68341
Others MTIF2 NCBI