2. Gene
  3. PPP1R12B - protein phosphatase 1 regulatory subunit 12B Gene

PPP1R12B - protein phosphatase 1 regulatory subunit 12B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MYPT2; PP1bp55

Gene ID: 4660 | Gene type: protein coding

About PPP1R12B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,348,699-202,592,702 (from NCBI)

This gene has 19 transcripts (splice variants), 145 orthologues and 3 paralogues. Broad expression in heart (RPKM 45.5), endometrium (RPKM 24.6) and 17 other tissues.

Summary

Myosin Phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein Phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin Phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase Phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

PPP1R12B Products(8)

mRNA Protein Name
NM_001167857.2 NP_001161329.1 protein phosphatase 1 regulatory subunit 12B isoform e
NM_001167858.2 NP_001161330.1 protein phosphatase 1 regulatory subunit 12B isoform f
NM_001197131.1 NP_001184060.1 protein phosphatase 1 regulatory subunit 12B isoform g
NM_001331029.2 NP_001317958.1 protein phosphatase 1 regulatory subunit 12B isoform h
NM_001410283.1 NP_001397212.1 protein phosphatase 1 regulatory subunit 12B isoform b
NM_002481.4 NP_002472.2 protein phosphatase 1 regulatory subunit 12B isoform a
NM_032103.3 NP_115286.1 protein phosphatase 1 regulatory subunit 12B isoform c
NM_032104.3 NP_115287.1 protein phosphatase 1 regulatory subunit 12B isoform d

PPP1R12B Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (64 - 152)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (210 - 280)

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  • 982 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 12B

myosin phosphatase target subunit 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10979 PPP1R12B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP1R12B RGD RGD:1309287
Canis familiaris PPP1R12B VGNC VGNC:44879
Bos taurus PPP1R12B VGNC VGNC:106875
Felis catus PPP1R12B VGNC VGNC:107924
Macaca mulatta PPP1R12B VGNC VGNC:76363
Mus musculus PPP1R12B MGD MGI:1916417