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GIMAP6 - GTPase, IMAP family member 6 Gene

Also Known as IAN2; IAN6; IAN-2; IAN-6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 474344

About GIMAP6

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,625,375-150,632,385 (from NCBI)

This gene has 3 transcripts (splice variants), 92 orthologues and 7 paralogues. Broad expression in spleen (RPKM 29.7), lymph node (RPKM 22.3) and 23 other tissues.

Summary

This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7. [provided by RefSeq, Sep 2011]

GIMAP6 Products (3)

mRNA	Protein	Name
NM_001244071.2	NP_001231000.1	GTPase IMAP family member 6 isoform 3
NM_001244072.2	NP_001231001.1	GTPase IMAP family member 6 isoform 2
NM_024711.6	NP_078987.3	GTPase IMAP family member 6 isoform 1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	23454188	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GIMAP6 Protein Structure

AIG1

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
GTPase IMAP family member 6	immune associated nucleotide 2

Related Diseases

Diseases	Alias
Lymphopenia	Lymphocytopenia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05426	GIMAP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21134	Gimap6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27652	Gimap6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GIMAP6	MGD	MGI:1918876
Canis familiaris	GIMAP6	VGNC	VGNC:106600
Macaca mulatta	GIMAP6	VGNC	VGNC:81315
Rattus norvegicus	GIMAP6	RGD	RGD:1305041
Others	GIMAP6	NCBI