2. Gene
  3. APC - APC regulator of WNT signaling pathway Gene

APC - APC regulator of WNT signaling pathway Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 479139 | Gene type: protein coding

About APC

Primary_assembly 3: 94,206-190,576 reverse strand.ROS_Cfam_1.0:CM025102.1

This gene has 5 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 1 phenotype.

APC Products(9)

mRNA Protein Name
XM_038660623.1 XP_038516551.1 adenomatous polyposis coli protein isoform X4
XM_038660624.1 XP_038516552.1 adenomatous polyposis coli protein isoform X4
XM_038660621.1 XP_038516549.1 adenomatous polyposis coli protein isoform X2
XM_038660626.1 XP_038516554.1 adenomatous polyposis coli protein isoform X6
XM_038660619.1 XP_038516547.1 adenomatous polyposis coli protein isoform X1
XM_038660625.1 XP_038516553.1 adenomatous polyposis coli protein isoform X5
XM_038660620.1 XP_038516548.1 adenomatous polyposis coli protein isoform X1
XM_038660618.1 XP_038516546.1 adenomatous polyposis coli protein isoform X1
XM_038660622.1 XP_038516550.1 adenomatous polyposis coli protein isoform X3

APC Protein Structure

APC_N_CC

APC_N_CC: pfam16689 (3 - 54)

Smc

Smc: cl34174 (13 - 261)

Suppressor_APC

Suppressor_APC: pfam11414 (126 - 206)

ARM

ARM: smart00185 (339 - 391)

APC_rep

APC_rep: pfam18797 (392 - 465)

ARM

ARM: sd00043 (489 - 525)

ARM

ARM: smart00185 (529 - 570)

ARM

ARM: sd00043 (533 - 570)

ARM

ARM: sd00043 (580 - 612)

ARM

ARM: sd00043 (620 - 661)

ARM

ARM: smart00185 (666 - 706)

ARM

ARM: sd00043 (670 - 704)

Arm

Arm: pfam00514 (708 - 748)

ARM

ARM: sd00043 (712 - 748)

Arm_APC_u3

Arm_APC_u3: pfam16629 (749 - 1036)

APC_u5

APC_u5: pfam16630 (1053 - 1152)

APC_r

APC_r: pfam05923 (1274 - 1291)

APC_u9

APC_u9: pfam16633 (1300 - 1385)

APC_r

APC_r: pfam05923 (1388 - 1410)

APC_r

APC_r: pfam05923 (1654 - 1677)

APC_u13

APC_u13: pfam16634 (1679 - 1732)

SAMP

SAMP: pfam05924 (1733 - 1754)

APC_u14

APC_u14: pfam16635 (1763 - 1856)

APC_r

APC_r: pfam05923 (1858 - 1882)

APC_u15

APC_u15: pfam16636 (1884 - 1964)

SAMP

SAMP: pfam05924 (2051 - 2070)

APC_basic

APC_basic: pfam05956 (2241 - 2586)

EB1_binding

EB1_binding: pfam05937 (2688 - 2861)

  • 0
  • 500
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  • 1500
  • 2000
  • 2500
  • 2862 a.a.
Protein Preferred Names Protein Names

adenomatous polyposis coli protein

APC, WNT signaling pathway regulator

adenomatosis polyposis coli

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112968 Human protein C / Unkown
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124955 proTAME Inhibitor 98.20% Unkown
HY-110287 Apcin Inhibitor 99.62% Unkown
HY-13255 TAME Inhibitor 99.51% Unkown
HY-130841 Apcin-A Inhibitor 98.0% Unkown
HY-P1918 Activated Protein C (390-404), human 98.74% Unkown
HY-13255A TAME hydrochloride Inhibitor 98.31% Unkown
HY-122142A Pyr-​Pro-​Arg-​pNA hydrochloride Substrate 99.24% Unkown
HY-126016 MAI-400 Inhibitor / Unkown
HY-P1918A Activated Protein C (390-404), human TFA / Unkown
HY-116473 CFM-1 Antagonist / Unkown
HY-112968A Bovine Protein C / Unkown
HY-172401 CDC20-IN-2 Inhibitor / Unkown
HY-122142 Pyr-​Pro-​Arg-​pNA Substrate / Unkown
HY-179012 CDC20/HSP90-IN-1 Inhibitor / Unkown
HY-W614725 Apcin-A monohydrochloride Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P992193 Anti-B7-H7 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens APC NCBI NCBI:324
Macaca fascicularis APC NCBI NCBI:102126553
Mus musculus APC NCBI NCBI:11789
Susscrofa domestica APC NCBI
Rattus norvegicus APC NCBI NCBI:24205