2. Gene
  3. NFX1 - nuclear transcription factor, X-box binding 1 Gene

NFX1 - nuclear transcription factor, X-box binding 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NFX2; Tex42; TEG-42

Gene ID: 4799 | Gene type: protein coding

About NFX1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,290,516-33,371,157 (from NCBI)

This gene has 6 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 8.4), lymph node (RPKM 6.5) and 25 other tissues.

Summary

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]

NFX1 Products(3)

mRNA Protein Name
NM_001318758.2 NP_001305687.1 transcriptional repressor NF-X1 isoform 4
NM_002504.6 NP_002495.2 transcriptional repressor NF-X1 isoform 1
NM_147134.4 NP_667345.1 transcriptional repressor NF-X1 isoform 3

NFX1 Protein Structure

zf-NF-X1

zf-NF-X1: NF-X1 type zinc finger (506 - 524)

zf-NF-X1

zf-NF-X1: NF-X1 type zinc finger (567 - 586)

zf-NF-X1

zf-NF-X1: NF-X1 type zinc finger (632 - 655)

zf-NF-X1

zf-NF-X1: NF-X1 type zinc finger (721 - 740)

zf-NF-X1

zf-NF-X1: NF-X1 type zinc finger (832 - 854)

R3H

R3H: R3H domain (1002 - 1059)

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  • 1120 a.a.
Protein Preferred Names Protein Names

transcriptional repressor NF-X1

nuclear transcription factor, X box-binding protein 1

Related Diseases

Diseases Alias
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09269 NFX1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NFX1 VGNC VGNC:32053
Rattus norvegicus NFX1 RGD RGD:1310277
Mus musculus NFX1 MGD MGI:1921414
Felis catus NFX1 VGNC VGNC:68490
Canis familiaris NFX1 VGNC VGNC:43788
Macaca mulatta NFX1 VGNC VGNC:103281