CNOT4 - CCR4-NOT transcription complex subunit 4 Gene

Also Known as NOT4; NOT4H; CLONE243

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4850

About CNOT4

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,361,795-135,510,102 (from NCBI)

This gene has 11 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin Ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

CNOT4 Products (12)

mRNA Protein Name
NM_001008225.3 NP_001008226.1 CCR4-NOT transcription complex subunit 4 isoform b
NM_001190847.2 NP_001177776.1 CCR4-NOT transcription complex subunit 4 isoform c
NM_001190848.2 NP_001177777.1 CCR4-NOT transcription complex subunit 4 isoform d
NM_001190849.2 NP_001177778.1 CCR4-NOT transcription complex subunit 4 isoform e
NM_001190850.2 NP_001177779.1 CCR4-NOT transcription complex subunit 4 isoform f
NM_001393370.1 NP_001380299.1 CCR4-NOT transcription complex subunit 4 isoform f
NM_001393371.1 NP_001380300.1 CCR4-NOT transcription complex subunit 4 isoform g
NM_001393372.1 NP_001380301.1 CCR4-NOT transcription complex subunit 4 isoform h
NM_001393373.1 NP_001380302.1 CCR4-NOT transcription complex subunit 4 isoform i
NM_001393374.1 NP_001380303.1 CCR4-NOT transcription complex subunit 4 isoform a
NM_001393375.1 NP_001380304.1 CCR4-NOT transcription complex subunit 4 isoform k
NM_013316.4 NP_037448.2 CCR4-NOT transcription complex subunit 4 isoform a

CNOT4 Protein Structure

zf-RING_4

zf-RING_4: RING/Ubox like zinc-binding domain (14 - 60)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (130 - 189)

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  • 500
  • 575 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 4

  • CCR4-associated factor 4

Related Diseases

Diseases Alias
Adenoiditis

  • Chronic Adenoiditis
Brachydactyly, Type E2

  • Brachydactyly Type E2

  • BDE2

  • Brachydactyly E2
Microphthalmia, Syndromic 1

  • MCOPS1

  • Lenz Microphthalmia Syndrome

  • Lenz Dysplasia

  • Mcops4

  • Syndromic Microphthalmia 1

  • Lenz Microphthalmia

  • Maa

  • Microphthalmia Or Anophthalmos With Associated Anomalies

  • Syndromic Microphthalmia Type 4

  • Microphthalmia, Syndromic 4

  • Microphthalmia, Syndromic 4, Formerly

  • Mcops4, Formerly

  • Anop1, Formerly

  • Maa, Formerly

  • Lenz Type Microphthalmia

  • Syndromic Microphthalmia 4

  • Microphthalmia Lenz Type

  • Microphthalmia Syndromic 1

  • Syndromic Microphthalmia Type 1

  • Microphthalmia Syndromic 4

  • Microphthalmia With Ankyloblepharon And Intellectual Disability

  • Microphthalmia, Lenz Type

  • Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

  • Microphthalmia, Syndromic, 1

  • Anop1

  • Microphthalmia, Syndromic, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02904 CNOT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CNOT4 RGD RGD:1310318
Mus musculus CNOT4 MGD MGI:1859026
Canis familiaris CNOT4 VGNC VGNC:39415
Macaca mulatta CNOT4 VGNC VGNC:71389
Felis catus CNOT4 VGNC VGNC:68518
Bos taurus CNOT4 VGNC VGNC:27519
Others CNOT4 NCBI