Brsk1 - BR serine/threonine kinase 1 Gene

Rattus norvegicus

Also known as Sad-b; RGD1563268

Gene ID: 499073 | Gene type: protein coding

About Brsk1

Summary

Enables protein serine/threonine kinase activity. Involved in neurotransmitter secretion. Located in distal axon and synaptic vesicle. Orthologous to human BRSK1 (BR serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Brsk1 Products(1)

mRNA	Protein	Name
NM_001127337.1	NP_001120809.1	serine/threonine-protein kinase BRSK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16630837	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16630837	RGD
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	25788287	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	16630837	RGD
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	16630837	RGD
involved in regulation of synaptic vesicle priming	IEP IEP: Inferred from expression pattern	16630837	RGD
involved in regulation of synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	16630837	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	16630837	RGD
is active in cholinergic synapse	IMP IMP: Inferred from mutant phenotype	16630837	RGD
located in distal axon	IMP IMP: Inferred from mutant phenotype	25788287	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	16630837	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	16630837	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	16630837	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase BRSK1

BR serine/threonine-protein kinase 1	brain-specific serine/threonine-protein kinase 1
serine/threonine-protein kinase SAD-B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01637	BRSK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Brsk1	NCBI	NCBI:84446

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