FCF1 - FCF1 rRNA-processing protein Gene

Also Known as Bka; UTP24; CGI-35; C14orf111

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51077

About FCF1

This gene has 8 transcripts (splice variants), 247 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 6.5), colon (RPKM 5.1) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

FCF1 Products (2)

mRNA Protein Name
NM_001318508.2 NP_001305437.1 rRNA-processing protein FCF1 homolog isoform 2
NM_015962.5 NP_057046.1 rRNA-processing protein FCF1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCF1 Protein Structure

Fcf1

Fcf1: Fcf1 (91 - 189)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

rRNA-processing protein FCF1 homolog

  • FCF1 small subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04825 FCF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FCF1 VGNC VGNC:104391
Mus musculus FCF1 MGD MGI:1920986
Macaca mulatta FCF1 VGNC VGNC:84338
Bos taurus FCF1 VGNC VGNC:28933
Rattus norvegicus FCF1 RGD RGD:1310899
Others FCF1 NCBI