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RLIM - ring finger protein, LIM domain interacting Gene

Also Known as MRX61; RNF12; TOKAS; NY-REN-43

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51132

About RLIM

Cytogenetic location: Xq13.2 Genomic coordinates (GRCh38): X:74,582,976-74,614,624 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is a RING-H2 Zinc Finger Protein. It has been shown to be an E3 ubiquitin protein Ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

RLIM Products (2)

mRNA	Protein	Name
NM_016120.4	NP_057204.2	E3 ubiquitin-protein ligase RLIM
NM_183353.3	NP_899196.1	E3 ubiquitin-protein ligase RLIM

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in random inactivation of X chromosome	IDA IDA: Inferred from direct assay	19945382	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RLIM Protein Structure

zf-RING_2

0
100
200
300
400
500
624 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RLIM	E3 ubiquitin-protein ligase RNF12

Related Diseases

Diseases	Alias
Tonne-Kalscheuer Syndrome	TOKAS Mrx61 Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia Mental Retardation, X-Linked 61 X-Linked Mental Retardation 61
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Retinitis Pigmentosa 24	RP24 Retinitis Pigmentosa-24
Non-Syndromic X-Linked Intellectual Disability 98	Mrx98 X-Linked Mental Retardation 98
Retinitis Pigmentosa 26	RP26 Retinitis Pigmentosa-26 Retinitis Pigmentosa, Type 26
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Syndromic Intellectual Disability
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12008	RLIM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22305	Rlim Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RLIM	MGD	MGI:1342291
Bos taurus	RLIM	VGNC	VGNC:56952
Macaca mulatta	RLIM	VGNC	VGNC:103853
Rattus norvegicus	RLIM	RGD	RGD:1559832
Felis catus	RLIM	VGNC	VGNC:97606
Canis familiaris	RLIM	VGNC	VGNC:54186
Others	RLIM	NCBI