GMIP - GEM interacting protein Gene

Also Known as ARHGAP46

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51291

About GMIP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,629,476-19,643,657 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 2 paralogues. Broad expression in spleen (RPKM 20.3), bone marrow (RPKM 16.1) and 21 other tissues.

Summary

This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GMIP Products (3)

mRNA Protein Name
NM_001288998.2 NP_001275927.1 GEM-interacting protein isoform 2
NM_001288999.2 NP_001275928.1 GEM-interacting protein isoform 3
NM_016573.4 NP_057657.2 GEM-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
12093360 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12093360 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12093360 GOA
involved in negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
12093360 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMIP Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (565 - 724)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 970 a.a.
Protein Preferred Names Protein Names

GEM-interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05520 GMIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GMIP VGNC VGNC:29436
Felis catus GMIP VGNC VGNC:62607
Macaca mulatta GMIP VGNC VGNC:72999
Mus musculus GMIP MGD MGI:1926066
Rattus norvegicus GMIP RGD RGD:1565577
Canis familiaris GMIP VGNC VGNC:41289
Others GMIP NCBI