ZDHHC3 - zinc finger DHHC-type palmitoyltransferase 3 Gene

Also Known as GODZ; DHHC3; DHHC-3; ZNF373

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51304

About ZDHHC3

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,915,261-44,976,174 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues and 17 paralogues. Ubiquitous expression in testis (RPKM 9.5), skin (RPKM 8.8) and 25 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in several processes, including TRAIL-activated apoptotic signaling pathway; protein localization to membrane; and protein localization to photoreceptor outer segment. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC3 Products (9)

mRNA Protein Name
NM_001135179.2 NP_001128651.1 palmitoyltransferase ZDHHC3 isoform 1
NM_001330761.2 NP_001317690.1 palmitoyltransferase ZDHHC3 isoform 4
NM_001349376.2 NP_001336305.1 palmitoyltransferase ZDHHC3 isoform 5
NM_001349377.2 NP_001336306.1 palmitoyltransferase ZDHHC3 isoform 6
NM_001349378.2 NP_001336307.1 palmitoyltransferase ZDHHC3 isoform 7
NM_001349379.2 NP_001336308.1 palmitoyltransferase ZDHHC3 isoform 8
NM_001349380.2 NP_001336309.1 palmitoyltransferase ZDHHC3 isoform 1
NM_001349381.2 NP_001336310.1 palmitoyltransferase ZDHHC3 isoform 1
NM_016598.3 NP_057682.1 palmitoyltransferase ZDHHC3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables palmitoyltransferase activity IDA
IDA: Inferred from direct assay
21926431 GOA
Biological Process GO Annotation Evidence References Source
involved in TRAIL-activated apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
22240897 GOA
involved in lipoprotein localization to membrane IMP
IMP: Inferred from mutant phenotype
22240897 GOA
involved in positive regulation of toll-like receptor 9 signaling pathway IDA
IDA: Inferred from direct assay
38169466 GOA
involved in protein localization to photoreceptor outer segment IDA
IDA: Inferred from direct assay
27613864 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
22240897 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
19001095 GOA
involved in protein palmitoylation IDA
IDA: Inferred from direct assay
21926431 GOA
involved in protein palmitoylation IMP
IMP: Inferred from mutant phenotype
19001095 GOA
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19001095 GOA
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
27613864 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16647879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC3 Protein Structure

DHHC

DHHC: DHHC palmitoyltransferase (93 - 254)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

palmitoyltransferase ZDHHC3

  • DHHC1 protein

Related Diseases

Diseases Alias
Neuronal Ceroid Lipofuscinosis

  • Hereditary Ceroid Lipofuscinosis

  • Batten Disease

  • Ncl

  • Neuronal Ceroid-Lipofuscinoses

  • Lipofuscinosis, Ceroid, Neuronal

  • Juvenile Neuronal Ceroid Lipofuscinosis

  • Cerebromacular Dystrophy

  • Cerebromacular Degeneration

  • Ceroid-Lipofuscinosis

  • Ncl - [Neuronal Ceroid Lipofuscinosis]

  • Amaurotic Familial Idiocy

  • Amaurotic Idiocy

  • Amaurotic Idiot

  • Neuronal Lipofuscinosis

  • Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16021 ZDHHC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZDHHC3 RGD RGD:1309041
Bos taurus ZDHHC3 VGNC VGNC:37141
Macaca mulatta ZDHHC3 VGNC VGNC:79143
Mus musculus ZDHHC3 MGD MGI:1926134
Canis familiaris ZDHHC3 VGNC VGNC:48591
Felis catus ZDHHC3 VGNC VGNC:67214