2. Gene
  3. AMZ2 - archaelysin family metallopeptidase 2 Gene

AMZ2 - archaelysin family metallopeptidase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 51321 | Gene type: protein coding

About AMZ2

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:68,206,129-68,257,164 (from NCBI)

This gene has 20 transcripts (splice variants), 169 orthologues and 1 paralogue. Broad expression in testis (RPKM 44.9), brain (RPKM 18.1) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc metalloprotease that displays some activity against angiotensin-3. The encoded protein is inhibited by the Aminopeptidase Inhibitor amastatin, as well as by the general inhibitors o-phenanthroline and batimastat. Defects in this gene may be associated with lung tumorigenesis. [provided by RefSeq, Oct 2016]

AMZ2 Products(23)

mRNA Protein Name
NM_001033569.2 NP_001028741.1 archaemetzincin-2 isoform 1
NM_001033570.2 NP_001028742.1 archaemetzincin-2 isoform 1
NM_001033571.1 NP_001028743.1 archaemetzincin-2 isoform 1
NM_001033572.1 NP_001028744.1 archaemetzincin-2 isoform 1
NM_001033574.2 NP_001028746.1 archaemetzincin-2 isoform 2
NM_001289054.2 NP_001275983.1 archaemetzincin-2 isoform 1
NM_001289056.2 NP_001275985.1 archaemetzincin-2 isoform 1
NM_001346471.1 NP_001333400.1 archaemetzincin-2 isoform 1
NM_001346472.1 NP_001333401.1 archaemetzincin-2 isoform 1
NM_001346473.1 NP_001333402.1 archaemetzincin-2 isoform 1
NM_001346474.2 NP_001333403.1 archaemetzincin-2 isoform 1
NM_001346475.2 NP_001333404.1 archaemetzincin-2 isoform 1
NM_001346476.2 NP_001333405.1 archaemetzincin-2 isoform 1
NM_001346477.2 NP_001333406.1 archaemetzincin-2 isoform 1
NM_001346478.2 NP_001333407.1 archaemetzincin-2 isoform 1
NM_001346479.2 NP_001333408.1 archaemetzincin-2 isoform 1
NM_001346480.1 NP_001333409.1 archaemetzincin-2 isoform 2
NM_001346481.1 NP_001333410.1 archaemetzincin-2 isoform 3
NM_001346482.1 NP_001333411.1 archaemetzincin-2 isoform 3
NM_001346483.2 NP_001333412.1 archaemetzincin-2 isoform 3
NM_001346484.2 NP_001333413.1 archaemetzincin-2 isoform 3
NM_001346485.2 NP_001333414.1 archaemetzincin-2 isoform 4
NM_016627.5 NP_057711.3 archaemetzincin-2 isoform 1

AMZ2 Protein Structure

Peptidase_M54

Peptidase_M54: Peptidase family M54 (233 - 297)

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  • 100
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  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

archaemetzincin-2

archaemetzincins-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00676 AMZ2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AMZ2 RGD RGD:1304846
Bos taurus AMZ2 VGNC VGNC:25878
Felis catus AMZ2 VGNC VGNC:97348
Canis familiaris AMZ2 VGNC VGNC:37843
Mus musculus AMZ2 MGD MGI:104837
Macaca mulatta AMZ2 VGNC VGNC:104568