CHMP3 - charged multivesicular body protein 3 Gene

Also Known as NEDF; VPS24; CGI-149

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51652

About CHMP3

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:86,503,430-86,563,443 (from NCBI)

This gene has 9 transcripts (splice variants), 208 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 41.6), thyroid (RPKM 40.0) and 25 other tissues.

Summary

This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with Other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

CHMP3 Products (3)

mRNA Protein Name
NM_001005753.3 NP_001005753.1 charged multivesicular body protein 3 isoform 2
NM_001193517.2 NP_001180446.1 charged multivesicular body protein 3 isoform 3
NM_016079.4 NP_057163.1 charged multivesicular body protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
17146056 GOA
enables molecular function inhibitor activity EXP
EXP: Inferred from Experiment
21827950 GOA
enables phosphatidylcholine binding IMP
IMP: Inferred from mutant phenotype
18687924 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14505570 GOA
enables ubiquitin-specific protease binding IPI
IPI: Inferred from physical interaction
18395747 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in late endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in midbody abscission IMP
IMP: Inferred from mutant phenotype
20616062 GOA
NOT involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
16554368 GOA
involved in multivesicular body-lysosome fusion IMP
IMP: Inferred from mutant phenotype
16554368 GOA
involved in nuclear membrane reassembly IMP
IMP: Inferred from mutant phenotype
26040713 GOA
NOT involved in nucleus organization IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in nucleus organization IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in plasma membrane repair IDA
IDA: Inferred from direct assay
24482116 GOA
involved in protein polymerization IDA
IDA: Inferred from direct assay
23051622 GOA
involved in regulation of centrosome duplication IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in regulation of early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
16554368 GOA
NOT involved in regulation of exosomal secretion IMP
IMP: Inferred from mutant phenotype
22660413 GOA
NOT involved in regulation of mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in suppression of viral release by host IMP
IMP: Inferred from mutant phenotype
16740483 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
17984323 GOA
involved in viral budding from plasma membrane IDA
IDA: Inferred from direct assay
24878737 GOA
involved in viral budding from plasma membrane IMP
IMP: Inferred from mutant phenotype
14505570 GOA
involved in viral budding via host ESCRT complex IDA
IDA: Inferred from direct assay
24878737 GOA
involved in viral budding via host ESCRT complex IMP
IMP: Inferred from mutant phenotype
16740483 GOA
involved in viral release from host cell IGI
IGI: Inferred from genetic interaction
23051622 GOA
involved in viral release from host cell IMP
IMP: Inferred from mutant phenotype
23051622 GOA
Cellular Component GO Annotation Evidence References Source
part of ESCRT III complex IDA
IDA: Inferred from direct assay
18687924 GOA
located in amphisome membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
16740483 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
26040712 GOA
located in kinetochore microtubule IDA
IDA: Inferred from direct assay
26040712 GOA
located in late endosome IDA
IDA: Inferred from direct assay
16554368 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in midbody IDA
IDA: Inferred from direct assay
26040712 GOA
located in multivesicular body membrane IDA
IDA: Inferred from direct assay
16554368 GOA
part of nuclear pore IDA
IDA: Inferred from direct assay
26040713 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16740483 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP3 Protein Structure

Snf7

Snf7: Snf7 (18 - 187)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

charged multivesicular body protein 3

  • 25.1 protein

Related Diseases

Diseases Alias
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

  • Ftd3

  • Frontotemporal Dementia, Chromosome 3-Linked

  • Amyotrophic Lateral Sclerosis, Chmp2b-Related

  • Chromosome 3-Linked Frontotemporal Dementia

  • FTDALS7

  • Chmp2b-Related Frontotemporal Dementia

  • Amyotrophic Lateral Sclerosis 17, Formerly

  • Als17, Formerly

  • Amyotrophic Lateral Sclerosis Type 17

  • Dtm1

  • Ftd-3

  • Ftd-Chmp2b

  • Als17

  • Amyotrophic Lateral Sclerosis 17

  • Sclerosis, Lateral, Amyotrophic, Type 17

  • Dementia, Frontotemporal, Chromosome 3-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02642 CHMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CHMP3 MGD MGI:1913950
Rattus norvegicus CHMP3 RGD RGD:708556
Others CHMP3 NCBI