STYXL1 - serine/threonine/tyrosine interacting like 1 Gene

Also Known as DUSP24; MKSTYX; MK-STYX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51657

About STYXL1

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,996,337-76,048,000 (from NCBI)

This gene has 11 transcripts (splice variants), 95 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 9.4), esophagus (RPKM 5.9) and 25 other tissues.

Summary

Enables protein Phosphatase binding activity; protein Phosphatase Inhibitor activity; and pseudophosphatase activity. Involved in several processes, including negative regulation of phosphoprotein Phosphatase activity; negative regulation of stress granule assembly; and positive regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

STYXL1 Products (6)

mRNA	Protein	Name
NM_001317785.2	NP_001304714.1	serine/threonine/tyrosine-interacting-like protein 1 isoform a
NM_001317786.2	NP_001304715.1	serine/threonine/tyrosine-interacting-like protein 1 isoform a
NM_001317787.2	NP_001304716.1	serine/threonine/tyrosine-interacting-like protein 1 isoform b
NM_001317788.2	NP_001304717.1	serine/threonine/tyrosine-interacting-like protein 1 isoform c
NM_001317789.1	NP_001304718.1	serine/threonine/tyrosine-interacting-like protein 1 isoform d
NM_016086.3	NP_057170.1	serine/threonine/tyrosine-interacting-like protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19026618	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	24709986	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	24709986	GOA
enables pseudophosphatase activity	IMP IMP: Inferred from mutant phenotype	20180778	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of stress granule assembly	IMP IMP: Inferred from mutant phenotype	20180778	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21262771	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	29250526	GOA
involved in regulation of intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	24709986	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	21262771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STYXL1 Protein Structure

Rhodanese

DSPc

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
serine/threonine/tyrosine-interacting-like protein 1	dual specificity phosphatase 24 (putative)

Related Diseases

Diseases	Alias
Seminal Vesicle Tumor	Tumor Of Seminal Vesicle Seminal Vesicle Neoplasm Seminal Vesicle Tumour Tumour Of Seminal Vesicle
Male Reproductive Organ Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13998	STYXL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STYXL1	VGNC	VGNC:35453
Felis catus	STYXL1	VGNC	VGNC:65824
Rattus norvegicus	STYXL1	RGD	RGD:1305845
Macaca mulatta	STYXL1	VGNC	VGNC:78158
Mus musculus	STYXL1	MGD	MGI:1923821
Others	STYXL1	NCBI