LUC7L3 - LUC7 like 3 pre-mRNA splicing factor Gene

Also Known as CRA; CROP; LUC7A; hLuc7A; CREAP-1; OA48-18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51747

About LUC7L3

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,719,603-50,756,219 (from NCBI)

This gene has 23 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 53.0), ovary (RPKM 46.4) and 25 other tissues.

Summary

This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

LUC7L3 Products (3)

mRNA Protein Name
NM_001330330.2 NP_001317259.1 luc7-like protein 3 isoform 2
NM_006107.4 NP_006098.2 luc7-like protein 3 isoform 1
NM_016424.5 NP_057508.2 luc7-like protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IMP
IMP: Inferred from mutant phenotype
10631324 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15798186 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA splicing IMP
IMP: Inferred from mutant phenotype
10631324 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12565863 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LUC7L3 Protein Structure

LUC7

LUC7: LUC7 N_terminus (5 - 252)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

luc7-like protein 3

  • CRE-associated protein 1

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Papillary, 1

  • Papillary Renal Cell Carcinoma

  • Hereditary Papillary Renal Cell Carcinoma

  • Papillary Renal Cell Carcinoma, Sporadic

  • Papillary Renal Cell Adenocarcinoma

  • RCCP

  • RCCP1

  • Renal Cell Carcinoma, Papillary

  • Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

  • Chromophil Carcinoma Of Kidney

  • Papillary Kidney Carcinoma

  • Sporadic Papillary Renal Cell Carcinoma

  • Chromophil Renal Cell Carcinoma

  • Papillary Renal Carcinoma, Malignant -

  • Papillary Renal Cell Carcinoma, Bilateral -

  • Papillary Renal Cell Carcinoma, Familial -

  • Papillary Renal Cell Carcinoma, Multiple -

  • Papillary Renal Cell Carcinoma, Sporadic -

  • Renal Adenocarcinoma

  • Chromophil Rcc

  • Hprcc

  • Renal Cell Carcinoma Papillary

  • Chromophilic Renal Cell Carcinoma

  • Prcc

  • Carcinoma, Renal Cell, Papillary, Type 1

  • Type 1 Papillary Renal Cell Carcinoma

  • Renal Cell Carcinoma

  • Hereditary Papillary Renal Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07890 LUC7L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LUC7L3 VGNC VGNC:42864
Mus musculus LUC7L3 MGD MGI:1914934
Rattus norvegicus LUC7L3 RGD RGD:1307981
Felis catus LUC7L3 VGNC VGNC:63328
Macaca mulatta LUC7L3 VGNC VGNC:74346
Bos taurus LUC7L3 VGNC VGNC:31080
Others LUC7L3 NCBI