Rgs14 - regulator of G-protein signaling 14 Gene

Also Known as RPIP1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 51791

Summary

Enables GTPase activating protein binding activity and GTPase activator activity. Involved in several processes, including learning or memory; negative regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within mitotic cell cycle. Located in several cellular components, including glutamatergic synapse; microtubule cytoskeleton; and postsynaptic density. Is expressed in decidua; embryo; hippocampus CA2; neural ectoderm; and placenta. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Apr 2022]

Rgs14 Products (2)

mRNA Protein Name
NM_001360714.1 NP_001347643.1 regulator of G-protein signaling 14 isoform 2
NM_016758.3 NP_058038.2 regulator of G-protein signaling 14 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activating protein binding IPI
IPI: Inferred from physical interaction
10926822 MGI
enables GTPase activator activity IDA
IDA: Inferred from direct assay
10926822 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10926822 MGI
Biological Process GO Annotation Evidence References Source
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
15525537 MGI
involved in learning IMP
IMP: Inferred from mutant phenotype
20837545 MGI
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
20837545 MGI
involved in long-term synaptic potentiation IDA
IDA: Inferred from direct assay
20837545 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15525537 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
28776200 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
28776200 MGI
involved in negative regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10926822 MGI
involved in negative regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
20837545 MGI
involved in negative regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
20837545 MGI
involved in nucleocytoplasmic transport IDA
IDA: Inferred from direct assay
15520006 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
10926822 MGI
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
15525537 MGI
involved in zygote asymmetric cell division IMP
IMP: Inferred from mutant phenotype
15525537 MGI
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
15520006 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10926822 MGI
located in dendrite IDA
IDA: Inferred from direct assay
20837545 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
20837545 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20837545 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28776200 MGI
located in nuclear body IDA
IDA: Inferred from direct assay
15520006 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15520006 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10926822 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20837545 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
20837545 MGI
located in spindle IDA
IDA: Inferred from direct assay
15525537 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of G-protein signaling 14

  • RAP1/RAP2-interacting protein

  • rap1/rap2 interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175763 Z55660043 Inhibitor / Unkown
HY-RS11907 RGS14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11909 Rgs16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs14 NCBI NCBI:10636