Rgs14 - regulator of G-protein signaling 14 Gene

Mus musculus

Also known as RPIP1

Gene ID: 51791 | Gene type: protein coding

About Rgs14

Summary

Enables GTPase activating protein binding activity and GTPase activator activity. Involved in several processes, including learning or memory; negative regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within mitotic cell cycle. Located in several cellular components, including glutamatergic synapse; microtubule cytoskeleton; and postsynaptic density. Is expressed in decidua; embryo; hippocampus CA2; neural ectoderm; and placenta. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Apr 2022]

Rgs14 Products(2)

mRNA	Protein	Name
NM_001360714.1	NP_001347643.1	regulator of G-protein signaling 14 isoform 2
NM_016758.3	NP_058038.2	regulator of G-protein signaling 14 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activating protein binding	IPI IPI: Inferred from physical interaction	10926822	MGI
enables GTPase activator activity	IDA IDA: Inferred from direct assay	10926822	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10926822	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	15525537	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	20837545	MGI
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	20837545	MGI
involved in long-term synaptic potentiation	IDA IDA: Inferred from direct assay	20837545	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15525537	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	28776200	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	28776200	MGI
involved in negative regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10926822	MGI
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	20837545	MGI
involved in negative regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	20837545	MGI
involved in nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	15520006	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	10926822	MGI
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	15525537	MGI
involved in zygote asymmetric cell division	IMP IMP: Inferred from mutant phenotype	15525537	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	15520006	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10926822	MGI
located in dendrite	IDA IDA: Inferred from direct assay	20837545	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	20837545	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20837545	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28776200	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	15520006	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15520006	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10926822	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	20837545	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	20837545	MGI
located in spindle	IDA IDA: Inferred from direct assay	15525537	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regulator of G-protein signaling 14

RAP1/RAP2-interacting protein

rap1/rap2 interacting protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175763	Z55660043	Inhibitor	/	Unkown
HY-RS11907	RGS14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11909	Rgs16 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgs14	NCBI	NCBI:10636

Name
Email *

	Sorry, but the email address you supplied was invalid.