PLAG1 - PLAG1 zinc finger Gene

Also Known as PSA; SGPA; SRS4; ZNF912

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5324

About PLAG1

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:56,160,909-56,211,273 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues, 29 paralogues and is associated with 82 phenotypes. Ubiquitous expression in ovary (RPKM 1.7), spleen (RPKM 1.3) and 23 other tissues.

Summary

Pleomorphic adenoma gene 1 encodes a Zinc Finger Protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PLAG1 Products (3)

mRNA	Protein	Name
NM_001114634.2	NP_001108106.1	zinc finger protein PLAG1 isoform a
NM_001114635.2	NP_001108107.1	zinc finger protein PLAG1 isoform b
NM_002655.3	NP_002646.2	zinc finger protein PLAG1 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10646861	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10646861	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10646861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAG1 Protein Structure

zf-H2C2_2

zf-C2H2

zf-H2C2_2

0
100
200
300
400
500 a.a.

Protein Preferred Names	Protein Names
zinc finger protein PLAG1	COL1A2/PLAG1 fusion

Related Diseases

Diseases	Alias
Salivary Gland Adenoma, Pleomorphic	Salivary Gland Pleomorphic Adenoma Sgpa Psa Adenomas, Salivary Gland Pleomorphic, Somatic Benign Epithelial Tumor Of Salivary Glands Pleomorphic Salivary Gland Adenoma Pleomorphic Adenoma Of Salivary Gland Adenomas, Salivary Gland Pleomorphic Adenoma, Salivary Gland, Pleomorphic, Somatic
Silver-Russell Syndrome 4	SRS4
Silver-Russell Syndrome 1	Silver-Russell Syndrome Russell-Silver Syndrome Silver-Russell Dwarfism Rss SRS1 Srs Silver Russell Dwarfism Russell Silver Syndrome Silver Russell Syndrome
Silver-Russell Syndrome Due To A Point Mutation
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Hepatoblastoma
Lipoblastoma
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Pleomorphic Adenoma Carcinoma	Carcinoma Ex Pleomorphic Adenoma Carcinoma In Pleomorphic Adenoma
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Epithelial-Myoepithelial Carcinoma	Clear Cell Adenoma Adenomyo-Epithelioma Clear Cell Carcinoma Emc Epithelial Myoepithelial Carcinoma Glycogen-Rich Adenocarcinoma Glycogen-Rich Adenoma Monomorphic Clear Cell Tumor Tubular Solid Adenoma Adenocarcinoma, Clear Cell
Vulvar Leiomyoma
Vulvar Benign Neoplasm
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Conventional Lipoma	Classic Type Lipoma
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Parachordoma
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Head And Neck Cancer	Head And Neck Neoplasm Head And Neck Tumours Head/Neck Neoplasm Tumor Of Head And Neck Head And Neck Neoplasms Hnc Cancer, Head/Neck
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Breast Myoepithelial Neoplasm	Breast Myoepithelial Tumor Malignant Breast Myoepithelioma
Breast Adenomyoepithelioma	Adenomyoepithelioma Of The Breast Breast Adenomyoepithelioma With Malignant Change Malignant Adenomyoepithelioma Of Breast
Apocrine Adenoma	Tubular Apocrine Adenoma
Gastrointestinal System Benign Neoplasm
Syringoma	Syringomas
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Spindle Cell Lipoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Sweat Gland Disease	Sweat Gland Diseases
Mulchandani-Bhoj-Conlin Syndrome	MBCS Maternal Uniparental Disomy Of Chromosome 20 Maternal Upd(20) Upd(20)Mat Uniparental Disomy, Maternal, Chromosome 20
Necrotizing Sialometaplasia	Sialometaplasia, Necrotizing
Myxoid Leiomyosarcoma	Leiomyosarcoma, Myxoid
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Vulvar Sarcoma	Sarcoma Of Vulva Vulva Sarcoma
Breast Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Breast Mucoepidermoid Carcinoma Of The Breast
Chondroid Lipoma
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Crisponi/Cold-Induced Sweating Syndrome 2	Cold-Induced Sweating Syndrome 2 CISS2 Sweating Syndrome, Cold-Induced, Type 2
Oropharynx Cancer	Oropharyngeal Cancer Oropharyngeal Carcinoma Malignant Neoplasm Of Oropharynx Malignant Oropharyngeal Tumor Malignant Tumor Of Oropharynx Malignant Tumour Of Mesopharynx Oropharyngeal Cancer, Adult Cancer Of The Oropharynx
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Mixed Cell Type Cancer	Malignant Mixed Neoplasm Malignant Mixed Tumor Mixed Neoplasm Mixed Tumor, Malignant Malignant Mixed Cancer Mixed Tumor Malignant Mixed Tumor, Not Otherwise Specified Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Temple Syndrome	Uniparental Disomy, Maternal, Chromosome 14 Temple Syndrome Due To Paternal 14q32.2 Microdeletion Paternal Del(14)(Q32.2) Temple Syndrome Due To Paternal 14q32.2 Hypomethylation Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14 Upd(14)Mat
Well-Differentiated Liposarcoma	Atypical Lipomatous Tumor Atypical Lipoma Alt Wdls Liposarcoma, Well Differentiated Pleomorphic Lipoma
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10643	PLAG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21690	Plag1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28208	Plag1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLAG1	VGNC	VGNC:32971
Felis catus	PLAG1	VGNC	VGNC:68887
Mus musculus	PLAG1	MGD	MGI:1891916
Rattus norvegicus	PLAG1	RGD	RGD:1305286
Canis familiaris	PLAG1	VGNC	VGNC:44638
Others	PLAG1	NCBI