Atoh7 - atonal bHLH transcription factor 7 Gene

Mus musculus

Also known as Math5; bHLHa13

Gene ID: 53404 | Gene type: protein coding

About Atoh7

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in entrainment of circadian clock by photoperiod. Acts upstream of or within circadian rhythm; entrainment of circadian clock; and neural retina development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in persistent hyperplastic primary vitreous. Orthologous to human ATOH7 (atonal bHLH transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Atoh7 Products(2)

mRNA	Protein	Name
NM_001364648.2	NP_001351577.1	transcription factor Atoh7 isoform 2
NM_016864.3	NP_058560.1	transcription factor Atoh7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	33712461	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within circadian rhythm	IMP IMP: Inferred from mutant phenotype	12451142	MGI
acts upstream of or within entrainment of circadian clock	IMP IMP: Inferred from mutant phenotype	12451142	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	26392540	MGI
acts upstream of or within neural retina development	IMP IMP: Inferred from mutant phenotype	21441919	MGI
involved in positive regulation of retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	33712461	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	33712461	MGI
involved in response to auditory stimulus	IMP IMP: Inferred from mutant phenotype	17977745	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17977745	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	33712461	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	17977745	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor Atoh7

helix-loop-helix protein mATH-5

protein atonal homolog 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01166	ATOH7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atoh7	NCBI	NCBI:220202

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