FXYD3 - FXYD domain containing ion transport regulator 3 Gene

Also Known as MAT8; PLML

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5349

About FXYD3

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,115,823-35,124,324 (from NCBI)

This gene has 14 transcripts (splice variants), 79 orthologues and 6 paralogues. Biased expression in colon (RPKM 158.8), stomach (RPKM 51.0) and 10 other tissues.

Summary

This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved Amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

FXYD3 Products (14)

mRNA Protein Name
NM_001136007.2 NP_001129479.1 FXYD domain-containing ion transport regulator 3 isoform 3
NM_001136008.2 NP_001129480.1 FXYD domain-containing ion transport regulator 3 isoform 4 precursor
NM_001136009.2 NP_001129481.1 FXYD domain-containing ion transport regulator 3 isoform 5 precursor
NM_001136010.2 NP_001129482.1 FXYD domain-containing ion transport regulator 3 isoform 5 precursor
NM_001136011.2 NP_001129483.1 FXYD domain-containing ion transport regulator 3 isoform 1 precursor
NM_001136012.2 NP_001129484.1 FXYD domain-containing ion transport regulator 3 isoform 2 precursor
NM_001387349.1 NP_001374278.1 FXYD domain-containing ion transport regulator 3 isoform 1 precursor
NM_001387350.1 NP_001374279.1 FXYD domain-containing ion transport regulator 3 isoform 1 precursor
NM_001387352.1 NP_001374281.1 FXYD domain-containing ion transport regulator 3 isoform 1 precursor
NM_001387353.1 NP_001374282.1 FXYD domain-containing ion transport regulator 3 isoform 1 precursor
NM_001387354.1 NP_001374283.1 FXYD domain-containing ion transport regulator 3 isoform 6 precursor
NM_001387355.1 NP_001374284.1 FXYD domain-containing ion transport regulator 3 isoform 7
NM_005971.4 NP_005962.1 FXYD domain-containing ion transport regulator 3 isoform 1 precursor
NM_021910.3 NP_068710.1 FXYD domain-containing ion transport regulator 3 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FXYD3 Protein Structure

ATP1G1_PLM_MAT8

ATP1G1_PLM_MAT8: ATP1G1/PLM/MAT8 family (25 - 72)

  • 0
  • 87 a.a.
Protein Preferred Names Protein Names

FXYD domain-containing ion transport regulator 3

  • chloride conductance inducer protein Mat-8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05167 FXYD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20024 Fxyd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26527 Fxyd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FXYD3 RGD RGD:620825
Mus musculus FXYD3 MGD MGI:107497
Canis familiaris FXYD3 VGNC VGNC:41021
Bos taurus FXYD3 VGNC VGNC:52196
Others FXYD3 NCBI