Gria3 - glutamate receptor, ionotropic, AMPA3 (alpha 3) Gene

Also Known as GluA3; Glur3; GluR-C; Glur-3; GluR-K3; Gluralpha3; 2900064I19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53623

Summary

This gene encodes a multi-pass transmembrane protein that forms a homotetramer or heterotetramer in neuronal cells. The encoded protein is a ligand-gated ion channel that responds to the neurotransmitter L-glutamate to promote synaptic transmission. Deficiency of this gene leads to behavioral phenotypes. The transcript is subject to RNA editing at codon 769 (AGA->GGA; R->G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gria3 Products (8)

mRNA Protein Name
NM_001281929.2 NP_001268858.2 glutamate receptor 3 isoform a precursor
NM_001290451.3 NP_001277380.2 glutamate receptor 3 isoform b precursor
NM_001358361.2 NP_001345290.2 glutamate receptor 3 isoform a precursor
NM_016886.5 NP_058582.4 glutamate receptor 3 isoform a precursor
NM_001281929.2 NP_001268858.2 glutamate receptor 3 isoform a precursor
NM_001290451.3 NP_001277380.2 glutamate receptor 3 isoform b precursor
NM_001358361.2 NP_001345290.2 glutamate receptor 3 isoform a precursor
NM_016886.5 NP_058582.4 glutamate receptor 3 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14687553 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
28103481 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
28103481 MGI
Biological Process GO Annotation Evidence References Source
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
28103481 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
located in membrane IDA
IDA: Inferred from direct assay
17093100 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
28103481 MGI
is active in parallel fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
28103481 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
19063943 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor 3

  • AMPA-selective glutamate receptor 3

  • glutamate receptor channel alpha3 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05793 GRIA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gria3 NCBI NCBI:2892