PNOC - prepronociceptin Gene

Also Known as NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5368

About PNOC

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,316,988-28,343,351 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 2 paralogues. Biased expression in brain (RPKM 7.7), lymph node (RPKM 5.0) and 8 other tissues.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

PNOC Products (2)

mRNA Protein Name
NM_001284244.2 NP_001271173.1 prepronociceptin isoform 2
NM_006228.5 NP_006219.1 prepronociceptin isoform 1 preproprotein

PNOC Protein Structure

Opiods_neuropep

Opiods_neuropep: Vertebrate endogenous opioids neuropeptide (20 - 66)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

prepronociceptin

  • nociceptin

Related Diseases

Diseases Alias
Postpartum Depression

  • Maternity Blues

  • Postnatal Depression

  • Depression, Postpartum

  • Post-Partum Depression

  • Depression Postpartum
Neonatal Abstinence Syndrome

  • Drug Withdrawal Syndrome In Newborn
Drug Dependence
Cluster Headache

  • Headache, Cluster
Wilson Disease

  • Hepatolenticular Degeneration

  • WD

  • Wilson'S Disease

  • WND

  • Westphal-Strumpell Syndrome

  • Copper Storage Disease

  • Cerebral Pseudosclerosis

  • Westphal Pseudosclerosis

  • Hepatolenticular Degeneration Syndrome

  • Copper Retention

  • Hepatocerebral Degeneration

  • Kinnier-Wilson Disease

  • Neurohepatic Degeneration

  • Progressive Hepatolenticular Degeneration

  • Lenticular Degenerative Disease

  • Wilson'S Syndrome

  • Lenticular Syndrome
Fibromyalgia

  • Diffuse Myofascial Pain Syndrome

  • Fibromyalgia Syndrome

  • Fibromyalgia-Fibromyositis Syndrome

  • Fibromyositis

  • Fibrositis

  • Fms

  • Myofascial Pain Syndrome

  • Myofascial Pain Syndromes
Paine Syndrome

  • Pain Disorder

  • Pain

  • Microcephaly With Spastic Diplegia

  • Pain Syndrome
Pain Agnosia

  • Analgesia
Opioid Abuse

  • Opioid-Related Disorders
Agnosia

  • Dyspraxia

  • Primary Visual Agnosia

  • Dyspraxia Syndrome

  • Monomodal Visual Amnesia

  • Visual Amnesia

  • Agnosia, Primary Visual

  • Apraxias

  • Alexia
Withdrawal Disorder

  • Withdrawal Syndrome

  • Substance Withdrawal Syndrome
Postsurgical Hypothyroidism

  • Postoperative Hypothyroidism

  • Post-Surgical Hypothyroidism
Opiate Dependence

  • Opioid Dependence

  • Opioid Addiction

  • Opiate Addiction

  • Opioid Type Dependence

  • Opioid-Related Disorders

  • Opium Dependence

  • Narcotic Dependence

  • Intravenous Narcotism

  • Narcotism Nos

  • Oral Narcotism Nos
Anxiety

  • Anxiety Disorder

  • Anxiety Disorders

  • Anxiety State

  • Anxieties

  • Anxiety Neurosis
Specific Developmental Disorder
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10788 PNOC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22283 Pnoc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28806 Pnoc Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PNOC VGNC VGNC:76200
Bos taurus PNOC VGNC VGNC:33089
Mus musculus PNOC MGD MGI:105308
Felis catus PNOC VGNC VGNC:68932
Rattus norvegicus PNOC RGD RGD:3362
Canis familiaris PNOC VGNC VGNC:44750
Others PNOC NCBI