Slc5a3 - solute carrier family 5 (inositol transporters), member 3 Gene

Also Known as Smit1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 53881

Summary

Predicted to enable glucose:sodium symporter activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in regulation of transporter activity. Acts upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of Reactive Oxygen Species biosynthetic process. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SLC5A3 (solute carrier family 5 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a3 Products (1)

mRNA	Protein	Name
NM_017391.3	NP_059087.2	sodium/myo-inositol cotransporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24595108	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within inositol metabolic process	IMP IMP: Inferred from mutant phenotype	16644257	MGI
acts upstream of or within myo-inositol transport	IMP IMP: Inferred from mutant phenotype	12582158	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	16174787	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	28128227	MGI
acts upstream of or within positive regulation of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	28128227	MGI
acts upstream of or within positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	28128227	MGI
acts upstream of or within regulation of respiratory gaseous exchange	IMP IMP: Inferred from mutant phenotype	12582158	MGI
involved in regulation of transporter activity	IDA IDA: Inferred from direct assay	24595108	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24595108	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	24595108	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	24595108	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sodium/myo-inositol cotransporter	Na(+)/myo-inositol cotransporter sodium myo-inositol transporter 1 solute carrier family 5, member 3 solute carrier family 5, member alpha 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13289	SLC5A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc5a3	NCBI	NCBI:6526