MPZ - myelin protein zero Gene
Species: Bos taurus
Summary
This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I Transmembrane Glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015]
MPZ Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001079507.2 | NP_001072975.1 | myelin protein P0 isoform MPZ precursor |
| NM_001316359.1 | NP_001303288.1 | myelin protein P0 isoform L-MPZ precursor |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
myelin protein P0 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS08633 | MPZ Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS22082 | Mpz Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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