2. Gene
  3. Cacna1e - calcium voltage-gated channel subunit alpha1 E Gene

Cacna1e - calcium voltage-gated channel subunit alpha1 E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cav2.3; CACHA1E

Gene ID: 54234 | Gene type: protein coding

About Cacna1e

Summary

Enables voltage-gated Calcium Channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in calcium ion import. Located in perikaryon. Part of voltage-gated Calcium Channel complex. Is active in GABA-ergic synapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 69. Orthologous to human CACNA1E (calcium voltage-gated channel subunit alpha1 E). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1e Products(1)

mRNA Protein Name
NM_019294.3 NP_062167.3 voltage-dependent R-type calcium channel subunit alpha-1E
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18940602 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
8388125 RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels EXP
EXP: Inferred from Experiment
19193890 RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
19193890 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion import IDA
IDA: Inferred from direct assay
21611731 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
19193890 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
19193890 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
19193890 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
19193890 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16736476 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
21611731 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent R-type calcium channel subunit alpha-1E

BII

RBE-II

RBE2

brain calcium channel II

calcium channel, L type, alpha-1 polypeptide

calcium channel, voltage-dependent, L type, alpha 1E subunit

calcium channel, voltage-dependent, R type, alpha 1E subunit

voltage gated calcium channel alpha1E su

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01795 CACNA1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1e NCBI NCBI:777