POLR2B - RNA polymerase II subunit B Gene

Also Known as RPB2; POL2RB; hRPB140

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5431

About POLR2B

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,978,896-57,031,158 (from NCBI)

This gene has 12 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 28.6), testis (RPKM 28.1) and 25 other tissues.

Summary

This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and MicroRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the FLAP loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

POLR2B Products (3)

mRNA Protein Name
NM_000938.3 NP_000929.1 DNA-directed RNA polymerase II subunit RPB2 isoform 1
NM_001303268.2 NP_001290197.1 DNA-directed RNA polymerase II subunit RPB2 isoform 2
NM_001303269.2 NP_001290198.1 DNA-directed RNA polymerase II subunit RPB2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-directed 5'-3' RNA polymerase activity IDA
IDA: Inferred from direct assay
9852112 GOA
enables RNA-dependent RNA polymerase activity IDA
IDA: Inferred from direct assay
23395899 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17998332 GOA
Biological Process GO Annotation Evidence References Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2B Protein Structure

RNA_pol_Rpb2_1

RNA_pol_Rpb2_1: RNA polymerase beta subunit (38 - 451)

RNA_pol_Rpb2_2

RNA_pol_Rpb2_2: RNA polymerase Rpb2, domain 2 (201 - 394)

RNA_pol_Rpb2_3

RNA_pol_Rpb2_3: RNA polymerase Rpb2, domain 3 (468 - 533)

RNA_pol_Rpb2_4

RNA_pol_Rpb2_4: RNA polymerase Rpb2, domain 4 (567 - 629)

RNA_pol_Rpb2_5

RNA_pol_Rpb2_5: RNA polymerase Rpb2, domain 5 (653 - 700)

RNA_pol_Rpb2_6

RNA_pol_Rpb2_6: RNA polymerase Rpb2, domain 6 (706 - 1080)

RNA_pol_Rpb2_7

RNA_pol_Rpb2_7: RNA polymerase Rpb2, domain 7 (1082 - 1172)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1174 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB2

  • DNA-directed RNA polymerase II 140 kDa polypeptide

Related Diseases

Diseases Alias
Fusariosis

  • Fusarium Infection
Eumycotic Mycetoma

  • Eumycetoma

  • Maduromycosis

  • Mycetoma

  • Madura Foot

  • Maduromycosis, Mycotic

  • Mycotic Mycetoma

  • Mycetoma Of Foot

  • Eumycotic Maduromycosis

  • Mycetoma Due To Fungal Infection
Dermatomycosis

  • Dermatomycoses
Basidiobolomycosis

  • Infection By Basidiobolus

  • Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum
White Piedra

  • Tinea Blanca

  • Trichosporosis Nodosa
Esophageal Atresia

  • Tracheoesophageal Fistula

  • Congenital Atresia Of Esophagus

  • Congenital Imperforate Esophagus

  • Imperforate Esophagus

  • Oesophageal Atresia

  • Te Fistula

  • Tef

  • Tracheoesophageal Fistula With Or Without Esophageal Atresia
Phaeohyphomycosis

  • Infection By Dematiacious Fungi

  • Phaehyphomycosis

  • Phaeomycosis

  • Pheohyphomycosis

  • Infection By Dematiacious Fungi [Phaehyphomycosis]

  • Dematiaceous Fungal Infection
Tinea Nigra

  • Microsporosis Nigra

  • Infection By Cladosporium Werneckii

  • Keratomycosis Nigricans

  • Tinea Palmaris Nigra

  • Keratomycosis Nigricans Palmaris
Otomycosis

  • Singapore Ear
Trichosporonosis
Adiaspiromycosis
Diamond-Blackfan Anemia 5

  • DBA5

  • Rpl35a-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 5
External Ear Disease

  • Diseases Of External Ear

  • Preauricular Cyst

  • Preauricular Sinus And Fistula

  • Preauricular Sinus Or Fistula
Esophageal Atresia/Tracheoesophageal Fistula

  • Esophageal Atresia And/Or Tracheoesophageal Fistula

  • Tracheoesophageal Fistula With Or Without Esohageal Atresia

  • Esophageal Atresia / Tracheoesophageal Fistula

  • Ea/Tef

  • Esophageal Atresia With Tracheoesophageal Fistula

  • Esophageal Atresia With Or Without Tracheoesophageal Fistula
Otitis Externa

  • Swimmer'S Ear

  • Infective Otitis Externa

  • Acute Infective Otitis Externa
Cockayne Syndrome

  • Cockayne'S Syndrome

  • Dwarfism-Retinal Atrophy-Deafness Syndrome

  • Neill-Dingwall Syndrome

  • Progeria-Like Syndrome

  • Progeroid Nanism

  • Cs
Superficial Mycosis

  • Piedra

  • Steroid-Modified Tinea Infection
Actinomycosis

  • Actinomycetoma

  • Boil

  • Canaliculitis

  • Actinomycotic Infection

  • Actinomycotic Madura Foot

  • Keratoactinomycosis

  • Furuncle

  • Actinomycotic Mycetema

  • Actinomycotic Mycetoma Of Foot

  • Madura Foot Due To Actinomadura

  • Actinomyces Israeli

  • Actinomycetes

  • Anaerobic Actinomyces Infection

  • Actinomycotic Infection Of Unspecified Site

  • Actinomycosis Nos

  • Actinomycotic Node

  • Actinomyces Infection

  • Actinomycotic Mycetoma

  • Mycetoma Due To Filamentous Bacteria
Sick Building Syndrome
Superficial Keratitis
Subcutaneous Mycosis

  • Subcutaneous Fungal Disease
Tinea Capitis

  • Dermatophytosis Of Scalp

  • Scalp Ringworm

  • Dermatophytosis Of Scalp Or Beard

  • Tinea Capitis Due To Trichophyton Rubrum

  • Trichophyton Rubrum Tinea Capitis
Fungal Infectious Disease

  • Mycoses

  • Mycosis
Dermatophytosis

  • Tinea

  • Dermatophytosis, Unspecified

  • Ringworm

  • Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

  • Cutaneous Mycosis

  • Dermal Mycosis

  • Superficial Mycosis, Unspecified

  • Fungus Infection Of Skin

  • Skin Mycosis

  • Dermatitis Fungoid

  • Fungal Dermatitis

  • Fungal Dermatosis

  • Mycotic Infection Of Skin
Autoimmune Lymphoproliferative Syndrome

  • ALPS

  • Canale-Smith Syndrome

  • Autoimmune Lymphoproliferative Syndrome, Type Ia

  • Autoimmune Lymphoproliferative Syndrome, Type Ib

  • Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

  • Css

  • Autoimmune Lymphoproliferative Syndrome, Type 1b

  • Autoimmune Lymphoproliferative Syndrome, Type 1a

  • Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

  • Fas Deficiency

  • Autoimmune Lymphoproliferative Syndrome 1a

  • ALPS1A

  • Autoimmune Lymphoproliferative Syndrome Type Ia

  • Autoimmune Lymphoproliferative Syndrome 1b

  • ALPS1B

  • Autoimmune Lymphoproliferative Syndrome Type Ib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10843 POLR2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta POLR2B VGNC VGNC:76211
Rattus norvegicus POLR2B RGD RGD:1309477
Canis familiaris POLR2B VGNC VGNC:44793
Mus musculus POLR2B MGD MGI:2388280
Bos taurus POLR2B VGNC VGNC:33136
Felis catus POLR2B VGNC VGNC:68947
Others POLR2B NCBI