Cacng3 - calcium channel, voltage-dependent, gamma subunit 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54376

Summary

Predicted to enable several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and voltage-gated Calcium Channel activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane and protein targeting. Located in glutamatergic synapse and somatodendritic compartment. Is integral component of postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in childhood absence epilepsy and macular degeneration. Orthologous to human CACNG3 (calcium voltage-gated channel auxiliary subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]

Cacng3 Products (1)

mRNA Protein Name
NM_019430.2 NP_062303.2 voltage-dependent calcium channel gamma-3 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18341993 MGI
Biological Process GO Annotation Evidence References Source
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
18753375 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
18753375 MGI
involved in protein localization IMP
IMP: Inferred from mutant phenotype
18341993 MGI
involved in protein targeting IMP
IMP: Inferred from mutant phenotype
18341993 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
27076426 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18753375 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18753375 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
27076426 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
18341993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-3 subunit

  • TARP gamma-3

  • neuronal voltage-gated calcium channel gamma-3 subunit

  • transmembrane AMPAR regulatory protein gamma-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01811 CACNG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacng3 NCBI NCBI:10368