Gabbr1 - gamma-aminobutyric acid (GABA) B receptor, 1 Gene

Also Known as GABAB1; GABAbR1; bM573K1.1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 54393

Summary

Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Located in several cellular components, including GABA-ergic synapse; Schaffer collateral - CA1 synapse; and synaptic membrane. Part of G protein-coupled receptor dimeric complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and respiratory system. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Gabbr1 Products (3)

mRNA	Protein	Name
NM_001413996.1	NP_001400925.1	gamma-aminobutyric acid type B receptor subunit 1 isoform 2 precursor
NM_001413997.1	NP_001400926.1	gamma-aminobutyric acid type B receptor subunit 1 isoform 3
NM_019439.4	NP_062312.3	gamma-aminobutyric acid type B receptor subunit 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	11498050	MGI
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	11498050	MGI
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	11498050	MGI
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	10075644	MGI
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	10075644	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15013631	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within gamma-aminobutyric acid signaling pathway	IDA IDA: Inferred from direct assay	20400944	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of G protein-coupled receptor dimeric complex	IDA IDA: Inferred from direct assay	20400944	MGI
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	11498050	MGI
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	11498050	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	11498050	MGI
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	11498050	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	11498050	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	11498050	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15013631	MGI
located in membrane	IDA IDA: Inferred from direct assay	20400944	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	20400944	MGI
located in presynapse	IDA IDA: Inferred from direct assay	21144999	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	20400944	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gamma-aminobutyric acid type B receptor subunit 1	GABA-B receptor 1 GABA-B-R1 GABA-BR1 GABA-BR1b receptor bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a) gb1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05204	GABBR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabbr1	NCBI	NCBI:2550