Fmn2 - formin 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54418

Summary

Predicted to enable actin binding activity. Involved in several processes, including Cytoskeleton organization; meiotic nuclear division; and oogenesis. Acts upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Located in several cellular components, including endoplasmic reticulum membrane; microvillus; and spindle. Is expressed in several structures, including brain; ganglia; neural ectoderm; otocyst; and testis. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Apr 2022]

Fmn2 Products (1)

mRNA Protein Name
NM_019445.2 NP_062318.2 formin-2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
23439682 MGI
involved in establishment of meiotic spindle localization IMP
IMP: Inferred from mutant phenotype
12447394 MGI
involved in formin-nucleated actin cable assembly IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in homologous chromosome movement towards spindle pole in meiosis I anaphase IMP
IMP: Inferred from mutant phenotype
12447394 MGI
involved in intracellular transport IMP
IMP: Inferred from mutant phenotype
21983562 MGI
acts upstream of or within meiotic chromosome movement towards spindle pole IMP
IMP: Inferred from mutant phenotype
23439682 MGI
involved in oogenesis IMP
IMP: Inferred from mutant phenotype
12447394 MGI
involved in polar body extrusion after meiotic divisions IMP
IMP: Inferred from mutant phenotype
12447394 MGI
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
21983562 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
21983562 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
21983562 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23439682 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23439682 MGI
located in microvillus IDA
IDA: Inferred from direct assay
23439682 MGI
located in spindle IDA
IDA: Inferred from direct assay
23439682 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

formin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161011 Spire2-FMN2 PPI-IN-1 Inhibitor / Unkown
HY-161011A Spire2-FMN2 PPI-IN-1 dihydrochloride Inhibitor 98.99% Unkown
HY-RS05001 FMN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fmn2 NCBI NCBI:56776