NLE1 - notchless homolog 1 Gene

Also Known as NLE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54475

About NLE1

This gene has 7 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 6.4), ovary (RPKM 4.9) and 25 other tissues.

Summary

Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NLE1 Products (2)

mRNA Protein Name
NM_001014445.2 NP_001014445.1 notchless protein homolog 1 isoform b
NM_018096.5 NP_060566.2 notchless protein homolog 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLE1 Protein Structure

NLE

NLE: NLE (NUC135) domain (17 - 77)

WD40

WD40: WD domain, G-beta repeat (105 - 142)

WD40

WD40: WD domain, G-beta repeat (148 - 184)

WD40

WD40: WD domain, G-beta repeat (192 - 232)

WD40

WD40: WD domain, G-beta repeat (236 - 272)

WD40

WD40: WD domain, G-beta repeat (279 - 357)

WD40

WD40: WD domain, G-beta repeat (363 - 400)

WD40

WD40: WD domain, G-beta repeat (404 - 442)

WD40

WD40: WD domain, G-beta repeat (452 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

notchless protein homolog 1

  • Notchless gene homolog

NLE1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89997 NLE1 Antibody (YA9341) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Pasteurellosis

  • Pasteurella Infection

  • Pasteurella Infections

  • Pasteurella Infectious Disease

  • Shipping Fever

  • Transport Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09338 NLE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NLE1 VGNC VGNC:32109
Canis familiaris NLE1 VGNC VGNC:43838
Felis catus NLE1 VGNC VGNC:63820
Macaca mulatta NLE1 VGNC VGNC:75217
Rattus norvegicus NLE1 RGD RGD:1308301
Mus musculus NLE1 MGD MGI:2429770
Others NLE1 NCBI